不同类型炎症中白细胞介素诸细胞因子水平变化及意义

Clincial significance of plasma levels of inflammatory factors in different kind of imflamatory response

目的研究感染性和自身免疫性炎症中白细胞介素（IL）诸细胞因子IL-1、IL-2、IL-6、IL-8、IL-12、IL-18和IL-4、IL-10、IL-13水平变化及变化持续时间的差异及其意义。方法应用放射性免疫法及双抗体夹心酶联免疫吸附法于不同时间检测感染性炎症75例（感染组）和自身免疫性炎症74例（自身免疫组）患者血清各因子含量值共8次，比较各因子变化情况及变化持续时间。结果IL-1、IL-2、IL-6、IL-8、IL-12、IL-18因子在两组差异有统计学意义（均P〈0．05）。入院2周后，感染组各因子检测水平开始降低并逐渐恢复至正常水平；自身免疫组多数因子则不能恢复至正常水平；两组各因子异常持续时间比较差异有统计学意义（P〈0．05）。IL-4、IL-10、IL-13因子在两组中差异有统计学意义（均P〈0．05）。入院1—2周后，感染组各因子检测水平开始降低并逐渐恢复至正常水平，自身免疫组不能恢复到正常水平，2组间异常持续时间差异有统计学意义（均P〈0．05）。结论细胞因子异常变化水平，特别是异常波动时间与炎症的性质及结局可能有内在因果关系。

Objective To evaluate the clinical significance of the levels and duration of elvafion of the interleukins （IL-1 ; IL-2 ; IL-6 ; IL-8 ; IL-12 ; IL-18 ） and （ IL-4 ; IL-10 ; IL-13 ） in two different types of inflammatory response. Methods The interleukins were measured by ELISA in 149 patients for eight times in different period. Resuits The interleukins levels of inflammatory eytokines showed the significant difference between groups （ P 〈 0.05 ）. After two weeks of admission, the levels of interleukins of infection group could return to normol gradually, those of the autoimmunities group could not. There was significant difference for rising duration of interleukins between two groups （P 〈 0.05 ）. There was singnificant difference for interleukins level of anti-inflammatory cytokines between two groups （ P 〈 0.05 ）. After one or two weeks of admission, the levels of interleukins of infection group could return to normol gradually, and those of the autoimmunitie group could not. There was significant difference for rising duration of interleukins between two groups （ P 〈 0.05 ）. Conclusion There maybe a causal relation among the abnormal cytokines levels especially the abnormal rising duration and inflammatory nature as well as outcome.