摘要
目的:检测survivin在上皮性卵巢癌组织中的表达,探讨survivin的表达与上皮性卵巢癌临床病理特征的关系。方法:应用免疫组织化学链霉亲和素-生物素-过氧化物霉复合物(SABC)方法,检测40例上皮性卵巢癌组织,20例良性上皮性卵巢肿瘤组织,20例正常卵巢组织中survivin的表达情况。结果:上皮性卵巢癌组织中survivin的阳性表达率为77.5%,高于良性上皮性卵巢肿瘤组织及正常卵巢组织的10%～0%(P<0.05),与组织学类型无相关性(P>0.05),与临床分期、组织学分级及淋巴结转移有关(P<0.05)。结论:survivin在上皮性卵巢癌组织中皆呈高表达,提示survivin可能与上皮性卵巢癌的浸润、转移有关。
Objective： To study the relationship between the expression of survivin with the histological type, grade, surgical stage and lymphatic metastasis in epithelial ovarian cancer. Methods： The expression of survivin in 40 case of epithelial ovarian cancers, 20 case of benign epithelial ovarian tumors and 20 case of normal ovarian tissues were detected by immunohistochemistry streptomycin - avidin - biotin - peroxidase complex （SABC） method. Results： Survivin was expressed 77. 5% （31/40） in epithelial ovarian cancers, 10% （2/20） in benign epithelial ovarian tumors and 0% （0/20） in normal ovarian tissues. The expression of survivin was significantly higher in epithelial ovarian cancers than that in benign epithelial ovarian tumors and normal ovarian tissues （P 〈 0. 01 ） . The overrexpression of survivin was related to the surgical stage histological grade and lymphatic metastasis, no relationship with the histological type （ P 〉 0.05 ） . Conclusion： The overexpression of survivin maybe related with the invasion and metastasis in epithelial ovarian cancer.
出处
《中国妇幼保健》
CAS
北大核心
2008年第8期1124-1126,共3页
Maternal and Child Health Care of China
