第Ⅷ因子相关抗原与复发性流产的相关性

Relationship between of factor Ⅷ related antigen and recurrent spontaneous abortion

目的:探讨子宫蜕膜组织血管内皮细胞第Ⅷ因子相关抗原对于复发性流产的病理诊断价值。方法:采用免疫组织化学SP法,对30例复发性流产患者(流产组)和10例正常孕妇(对照组)的子宫蜕膜血管进行免疫病理观察。结果:流产组蜕膜血管内皮细胞第Ⅷ因子相关抗原缺失(阴性),对照组完好(阳性),两组比较有极显著性差异(P<0.001)。结论:复发性流产患者子宫蜕膜血管内皮细胞第Ⅷ因子相关抗原的表达缺失,反映了血管受到免疫复合物的损伤,此检测可作为病理诊断指标。

Objective： To investigate the value of pathological diagnosis of factor W related antigen in recurrent spontaneous abortion （RSA） . Methods： The decidua vessels were studied by immunohistochemical SP methed in 80 cases of lISA and 10 cases of normal pregnant women （control group） . Results： In 30 cases of RSA, the depositions of facter Ⅷ related antigen were lacked, compared with control group （P 〈 0. 001 ） . Conclusion： In RSA cases, the depositions of facter Ⅷ related antigon are lacked, it may have a sort of indicate in pathological diagnosis.