妊娠期肝内胆汁淤积症血清胆汁酸与围生结局分析

Analysis of serum bile acid in patients with intrahepatic cholestasis of pregnancy and perinatal outcome

目的探讨高胆汁酸水平是否增加妊娠期肝内胆汁淤积症(ICP)母婴严重并发症的发生率。方法对我院2006年1月—2007年1月收治的资料完整的56例ICP患者临床资料进行回顾性分析,按照血清胆汁酸水平分为<50μmol/L和≥50μmol/L组,分析统计严重母婴并发症的发生率,并进行统计学分析。结果2组化验检查结果及母婴严重并发症包括早产、羊水粪染、剖宫产、新生儿窒息、产后出血等发生率有显著性差异(P<0.05)。结论高胆汁酸水平孕妇母婴严重并发症增多,但单纯依据高胆汁酸不应作为判断ICP患者选择结束妊娠的主要指标。

Objective It is to discuss whether the high bile acid level increases the incidence rate of female infant serious complication in patients with intrahepatic cholestasis of pregnancy （ICP）. Methods 56 patients of ICP with complete data who were in our hospital from Jan, 2006 to Jan, 2007 were analyzed retrospectively. They were divided into group A （ 〈 50 μmol/L） and group B （≥50 μmol/L） according to serum bile acid level. The incidence rate of female infant serious complication was observed and analyzed statistically. Results There was significant difference on the inspection result and the incidence rates of female infant serious complication include premature delivery, meconium stained amniotic fluid, cesarean section, neonatal asphyxia, the postnatal hemorrhage and so on between the two groups （P 〈 0.05 ）. Conclusion The female infant serious complication increases in pregnancy patients with high bile acid level, but according to high bile acid level only should not be the major index to stop pregnancy of ICP patients.