摘要
以辛可宁为原料,经Mitsunobu反应合成了9-氨基(9-脱氧)表辛可宁,然后分别与对甲苯磺酰氯、对氯苯磺酰氯反应,合成了两个新手性磺酰胺,其结构经红外光谱和核磁共振确证。
9-Amino（9-deoxy）epicinchonine was synthesized from cinchonine through the Mitsunobu reaction and was treated with p-toluenesulfonyl chloride, 4-chlorobenzenc suffonyl chloride respectively to give two new chiral sulfonamides. The structures of sulfonamides had been determined by IR and IHNMR spectrometry.
出处
《化学试剂》
CAS
CSCD
北大核心
2008年第3期213-214,共2页
Chemical Reagents
基金
湖北省自然科学基金资助课题(2007ABA291)
关键词
辛可宁
磺酰胺
合成
cinchonine
sulfonamide
synthesis
