摘要
目的研究降钙素基因相关肽(CGRP)舒血管物质对急性肾功能衰竭(ARF)的影响,探讨CGRP和内皮素-1(ET-1)在ARF中的变化和作用。方法运用放免法检测大鼠不同时间血浆CGRP、ET-1水平的变化,并检测大鼠的肾功指标,对其进行评估。结果甘油所致ARF大鼠血浆CGRP水平明显降低(P<0.05);血浆ET水平明显增高(P<0.01)。结论血浆CGRP、ET-1含量测定可以作为反映肾功能状态和分析ARF病程发展与转归的敏感指标。CGRP对ARF时的肾脏有保护功能。
Objective To study the effects of CGRP and ET - 1 and to evaluate their changes during ARF. Methods The levels of CGRP and ET - 1 in serum were measured by radioimmunity and was evaluated the renal function. Results The level of CGRP decreased significantly （ P 〈 0.05 ）, and the level of ET - 1 increased significantly （ P 〈 0.01 ） in serum. Conclusion The levels of CGRP and ET - 1 in serum could reflect the renal functional state and clinical course in ARF. CGRP had a protected effect on the ischemic kidney.
出处
《中国辐射卫生》
北大核心
2008年第1期10-12,共3页
Chinese Journal of Radiological Health
