痛经舒口服液对大鼠子宫平滑肌及其前列腺素F_(2α)含量的影响

The Effect of Tongjingshu Oral Liquid on the Smooth Muscle Constriction and the Level of Prostaglandins F_(2α) from the Uterus of Rats

目的探讨痛经舒口服液对大鼠子宫平滑肌作用,及对痛经模型大鼠子宫平滑肌前列腺素F2α含量的影响。方法皮下注射乙烯雌酚及腹腔注射氯前列稀醇(前列腺素F2α类似物)或缩宫素,诱发大鼠痛经,灌胃给予痛经舒口服液,观察痛经舒口服液对子宫平滑肌的收缩频率及幅度的影响,检测子宫组织中前列腺素F2α含量。结果痛经舒口服液对前列腺素F2α类似物或缩宫素所致大鼠体内、体外子宫平滑肌痉挛性收缩有明显的阻断作用,使子宫平滑肌前列腺素F2α含量下降。结论痛经舒口服液能缓解痛经,对原发性痛经模型大鼠有保护作用。

Objective To study the effect of tongjingshu oral liquid on the smooth muscle constriction and the level of prostaglandins F2α from the uterus of rats under dysmenorrhea situation. Methods Dysmenorrhea was induced by diaethy lstilbestrol subcutaneous injection, or cloprostenol or oxytocin celiac injection. After tongjingshu oral liquid gastric perfusion, the frequency and range of the smooth muscle constriction were determined, and the level of the prostaglandins F2α was detected. Results The smooth muscle constriction resulted from such as prostaglandins F2α or oxytocin was able to be strongly relaxed by tongjingshu oral liquid, which also might decline the level of the prostaglandins F2α in the smooth muscle. Conclusion Tongjingshu oral liquid is a effective agent to relieve the dysmenorrhea and protect from the primary dysmenorrheal in the rats.