摘要
目的探讨丙泊酚自控镇静在甲状腺切除术中的安全性及应用价值。方法ASAⅠ-Ⅱ级拟行甲状腺次全切除术的患者60例,随机分为丙泊酚自控镇静组(P组)和对照组(C组),每组30例。P组手术开始时给予负荷量50 mg,然后开始患者自控镇静。给药模式为:每次给药量10 mg,每次给药时间0.33 min,锁定时间1 min,有效锁定时间1.33 min,5 min最大给药量30 mg,手术结束前5 min停药。C组手术开始时给予哌替啶1 mg.kg-1+异丙嗪1 mg·kg^-1加入输液滴壶静脉滴注,术中不再追加其他镇静药物。监测两组术前、术中30 min及术后患者的收缩压(SBP)、心率(HR)及血氧饱和度(SpO2),并记录镇静分数、合作分数及满意分数。结果P组术中30 min时SBP、HR、SpO2与C组同期相比差异有显著性(P〈0.05),P组的镇静分数明显低于C组(P〈0.01),而合作分数和满意分数明显高于C组(P〈0.05)。结论丙泊酚自控镇静可安全应用于甲状腺切除术,能很好地减轻患者焦虑,获得更高的满意度。
Objective To evaluate the safety and efficacy of propofol patient-controlled sedation (PCS) as a local anethesia in thyroidectomy . Methods Sixty patients (ASAⅠ-Ⅱ) undergoing thyroidectomy were randomly divided into group P(pcs,n=30) and group C(control, n=30). In group P, after 50 mg of propofol as a loading dose, the patient-controlled sedation was induced by propofol using the Graseby9300PCA pump. Therapy procedurse were consisted of a lockout interval of one minute and a dose of propofol 10 mg, and 30 mg is the maximum dose in 5 minutes. Group C was only given pethidine 1 mg·g^-1 and promethazine 0.5 mg · kg^-1. Systolic blood pressure(SBP), heart rate(HR), serum oxygen saturation (SPO2 ) were recorded before infusion, 30 minutes after infusion and 5 minutes after operation. Sedation scores, cooperation degrees and satisfaction were also measured. Results The SBP, HR and SpO2 in group P were significiantly different from group C at the 30 minutes after infusion. Sedation scores were lower in group P (P〈0.01) , while cooperation and satisfaction scores were higher than that in group C (P〈 0.05). Conclusions Propofol patient-controlled sedation is a safe and effective method with high satisfaction for thyroidectomy.
出处
《医药导报》
CAS
2008年第3期296-298,共3页
Herald of Medicine
关键词
丙泊酚
自控镇静
甲状腺切除术
Propofol
Patient-controlled sedation(PCS)
Thyroidectomy