摘要
目的估算米氏消除药物血管外给药的药动学参数。方法四阶Runge-Kutta算法获得血药浓度的模拟值,根据模拟取样点的药时数据,以△C/△t近似地代替微分式dC/dt,血药浓度(C)采用算术均数(Ci+Ci+1)/2;采用SPSS软件中的非线性回归(non linear regression)对△C/△t-C数据对拟合药动学参数。结果SPSS估算的药动学参数准确可靠。结论SPSS可用于估算米氏消除药物血管外给药的药动学参数。
Objective To estimate the pharmacokinetic parameters for drug obeying one order adsorption and Michaelis-Menten elimination by SPSS（statistics package for social science, 12.0） software. Methods Concentration-time data obtained from four order Runge-Kutta algorism with excel forms were converted into △C/△t at a sere of sampling time. The dC/dt was approximately replaced by △C/△t,and concentration c was accounted by an arithmetic mean of（Ci＋Ci＋1）. Data of A C△/△ t-c were analogized by nonlinear regression of SPSS. Results The pharmacokinetic parameters estimated by SPSS were accurate and reliable. Conclusion SPSS is suitable for estimating the pharmacokinetic parameters of drugs obeying one order adsorption and Michaelis-Menten elimination.
出处
《医药导报》
CAS
2008年第3期333-336,共4页
Herald of Medicine
基金
温州市科技局社会发展基金资助项目(基金编号:Y2003A075)
关键词
SPSS软件
药动学
米氏消除
一级吸收
SPSS software
Pharmacokinetics
Michaelis-Mentenelimination
One order adsorption
