腹部外科手术后MODS患者内分泌及免疫功能的改变

Changes of endocrine and immunity in MODS patients undergoing abdominal surgical operations

目的探讨腹部外科手术后MODS患者内分泌及免疫功能的改变。方法检测MODS组20例及非MODS组34例患者术前及术后1、3、7d外周血清TNF,IL-6,T3,T4,rT3,FT3,FT4,GH,C3,C4,CRP水平,进行统计学分析。结果MODS患者内分泌及免疫功能的改变大于非MODS患者。T3,T4,FT3,FT4较非MODS组显著性下降(P<0.05),rT3,GH较非MODS组显著性升高(P<0.05)。TNF,IL-6,CRP较非MODS组显著性升高(P<0.05)。C3,C4较非MODS组显著性下降(P<0.05)。结论MODS状态下出现的内环境紊乱,不仅有免疫失衡,神经及内分泌功能也有不同程度的改变。

Objective To research the changes of endocrine and immunity in MODS patients after abdominal surgical operations. Methods Fifty - four subject to abdominal surgical operations were selected and divided into MODS group and control group. The levels of serum TNF, IL - 6, Ta , T4, rT3, FT3, FT4, GH, Ca, C4 and CRP were determined before and after operation （ 1 st, 3rd, 7th day）. Results Ta,T4, FT3, FT4, Ca and C4 levels were significantly reduced in MODS group as compared with those in control group （P 〈 0.05 ）. rT3 , GH, TNF, IL - 6 and CRP were increased significantly in MODS group as compared with control group （ P 〈 0.05 ）. Conclusion There was internal enviroment disorder in MODS, which included changes of endocrine system and immune system.