针刺配方对中风患者血浆中GMP-140的影响及临床疗效观察

Influences of Acupuncture Prescriptions on Serum GMP-140 and Their Clinical Effects in Stroke Patients

目的观察三组针刺配方对中风(脑梗死)患者临床疗效及血浆中GMP-140的影响,筛选最佳组方。方法将入选的90例脑梗死(急性期)患者随机分成三组,A组(阳经穴位组)、B组(阴经穴位组)、C组(阴阳经联合组)。经过21天治疗,观察三组临床疗效及治疗前后脑梗死患者血浆中GMP-140的变化及三组间疗后比较。结果三组均可使脑梗死(急性期)患者神经功能有所恢复,阴阳经联合组的临床有效率高于阳经穴位组、阴经穴位组(P<0.05);三组均可使脑梗死(急性期)患者血浆中GMP-140有不同程度下降,治疗前后比较均有所改善(P<0.05),阴阳经联合组使脑梗死(急性期)患者血浆中GMP-140下降程度明显高于阳经穴位组、阴经穴位组(P<0.05)。结论运用阴阳经联合配方针刺治疗脑梗死(急性期)患者能够提高临床疗效并可使其血浆中GMP-140含量显著下降,从而降低血小板的高活性,改善血小板活化程度,改善血液粘、凝、聚的病理状态,改善脑供血,防止血栓蔓延,促进肢体功能恢复。

Objective To investigate the clinical therapeutic effects of three acupuncture prescriptions on stroke （ cerebral infarction） and their influences on serum GMP-140 in the patients and sift out the optimal prescription. Methods Ninety cerebral infarction （acute stage） patients were recruited and randomly allocated to three groups： A （yang meridian points） , B （yin meridian points） and C （combined yin and yang meridian points）. After twenty-one days＇ treatment, the clinical therapeutic effects were evaluated and changes in serum GMP-140 examined in the three groups of patients, and the posttreatment outcomes were compared between the three group. Results Neural function was restored in all the three groups of cerebral infarction （acute stage） patients. The clinical efficacy rate was significantly higher in group C than in group A and B （P 〈 0.05）. Serum GMP-140 was reduced to a significantly larger extent in group C than in group A and B （P 〈 0.05）. Conclusion Acupuncture of combined yin and yang meridian points can heighten the clinical therapeutic effect on cerebral infarction （acute stage） and significantly decrease serum GMP-140 content, thereby reducing high platelet activity, improving the degree of platelet activation and the pathological blood viscosity and erythrocyte aggregation, ameliorating cerebral blood supply, preventing thrombus spreading and promoting the recovery of limb function.