摘要
目的:观察癫痫发作前、发作时及发作后血浆去甲肾上腺素(NE)及血清心肌肌钙蛋白I(cTnI)含量以及心脏病理变化。探讨癫痫发作致心脏损害的发生、发展机制。方法:健康Wistar大鼠40只随机分成癫痫组(EP)和对照组(Control)。癫痫由青霉素诱导发作,动态监测大鼠癫痫发作时和发作后不同时间点血浆NE含量及血清cTnI水平的变化。NE的测定采用高效液相-电化学法,cTnI的测定采用光化学发光法。结果:大鼠癫痫发作时血浆NE明显升高,NE升高持续约1h以上。癫痫发作后1h血清cTnI水平开始升高,12h达高峰,随后逐渐下降。心脏病理检查证实癫痫发作可引起心脏损害。结论:癫痫发作时NE含量升高在癫痫发作致心脏损害过程中起重要作用。
Objective： To observe the changes of plasma noradrenaline （NE） and serum cardiac tropin I （cTnI） during epileptic seizure and after that in different time, and discuss the mechanism of cardiac injury result from epileptic seizure. Methods： 40 adult healthy Wistar rats were randomly divided into epilepsy group and control group, and epileptic seizures were induced by penicillin. NE and cTriI were determined by hlgh-performance-liquid chromatography and automated chemiluminescence method. We observed the changes of plasm NE and serum cTnI during and after seizure at lh, 6h, 12h, 24h and 48h,respectively. Results： NE activity in plasma obviously increased during epileptic seizure, which lasted about 1 hour. Serum cTnI elevated at lh after seizure, and reached the peak at 12h, then gradually decreased. Cardiac injury during epileptic seizure was proved by pathologic examination. Conclusion：The enhanced activity of peripheral NE may play an important role in cardiac injury result from epileptic seizure.
出处
《陕西医学杂志》
CAS
北大核心
2008年第3期289-291,共3页
Shaanxi Medical Journal
