4329例手术后食管癌临床病理资料分析

Analysis of Clinicopathologic Features of Esophageal Cancer Patients after Surgery-a Report of 4,329 Cases

目的:了解食管癌在河北省南部地区的发病情况,探究其发生发展现状。方法:选取1996年1月1日～2005年12月31日在河北医科大学第四医院行手术的食管癌患者共4329例,收集其病理资料并进行统计分析。结果:十年来平均发病年龄有上升的趋势(P<0.05)。鳞癌构成比有下降趋势(P<0.05),小细胞癌构成比有增多趋势(P<0.05)。临床分期Ⅱ期患者构成比下降(P<0.05),而Ⅳ期患者构成比增加(P<0.05)。上、中、下段各发病部位在性别、年龄、病理类型、浸润深度、分期构成比及淋巴结转移率方面均有统计学差异(P<0.05)。结论:本地区食管癌患者就诊偏晚,鳞癌构成比下降,小细胞癌构成比上升,而腺癌由于发病率较低,10年来构成比未见明显上升趋势。

Objective： To investigate the clinlcopathologic features of esophageal cancer （EC） patients after surgery in the Fourth Hospital of Heibei Medical University, and to analyze the epidemiologic characteristics of esophageal cancer in the south of Hebei Province. Methods： A total of 4,329 patients with esophageal cancer seen in our hospital from January 1996 to Deeemher 2005 were seleeted. All clinieal information were collected and analyzed by SAS 6.0 software package. Results： The patients＇ age showed an ascending tendency from 1996 to 2005. The constituent ratio of the squamous esophageal cancer showed a descending tendency, and that of the oat cell carcinoma showed an ascending tendency. The constituent ratio of stage Ⅱ showed a descending tendency, while that of stage Ⅳ showed an ascending tendency. The ratio of gender, age, pathological type, infiltrative depth, clinical stage and lymph node metastasis were statistically different among the three segments of esophageal cancer （P〈0.05）. Conclusion： EC patients in Hebei province eonsuh at a late time. From 1996 to 2005, the constituent ratio of the squamous esophageal cancer showed a descending tendency, and that of the oat cell carcinoma showed an ascending tendency. The constituent ratio of adenoeareinoma showed no changes.