B-myb C-myc在肝细胞性肝癌中的表达及临床意义

Expression of B-myb and C-myc in Hepatocellular Carcinoma and Its Clinical Significance

目的:检测肝细胞性肝癌(hepatocellular carcinoma,HCC)中B-myb及C-myc蛋白的表达情况,探讨其在肝癌发生、发展及转移中的作用。方法:采用免疫组化法检测60例肝癌组织及60例癌旁肝组织中B-myb和C-myc的表达情况。结果:B-myb、C-myc在癌组织中的阳性率分别为56.67%和53.33%,而在癌旁组织中的阳性率分别为36.67%和35.00%,癌组织与癌旁组织比较差异有显著性(P<0.05)。B-myb在肝癌组织中的表达与临床分期、肝外转移、术后复发肿瘤个数及包膜完整相关(P均<0.05);C-myc在肝癌组织中的表达与门静脉癌栓、肝外转移、术后复发、肿瘤分化程度及包膜完整相关(P均<0.05)。B-myb与C-myc在癌组织中的表达正相关。结论:B-myb及C-myc蛋白的过表达,可促使肝癌细胞增殖,使肝癌细胞具有更强的侵袭力,与肝癌的发生、发展密切相关。

Objective： To detect the expression of B-myb and C-myc in hepatoeellular carcinnma（HCC） tissues and to explore its significance in the occurrence, progression and metastasis of HCC. Methods： Immunohistochemisty was employed to detect the expression of B-myb and C-myc in 60 samples of HCC tissues and their adjacent liver tissues. Resuits： The positive rates of B-myb anti C-myc in the HCC tissues were higher than in the adjacent liver tissues （56.67% and 53.33% vs. 36.67% and 35%, P〈0.05）. The expression of B-myb in the HCC tissues was significantly eorrelated with the clinical stage, the presence of extrahepatic metastasis, the recurrence of tumor, the number of tumors, and capsule of tumor. The expression of C-myc in the HCC tissues was significantly correlated with portal vein tumor thrombus, the presence of extrahepatic metastasis, the recurrence of tumor, the differentiation and capsule of tumor. The expression of B- myb was positively correlated with the expression of C-myc in HCC tissues. Conclusion： The over-expression of B-myb and C-myc proteins may contribute to the proliferation of hepatocellular carcinoma cells and is related to the occurrence and progression of HCC.