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sdf-1及其受体在成体干细胞迁移中的作用 被引量：6

Roles of SDF-1/CXCR4 in adult stem cell migration
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摘要 基质细胞衍生因子是一种干细胞趋化因子,它可以通过与其受体CXCR4结合,调控干细胞定向迁移,发挥特定的生物学效应。SDF-1/CXCR4轴在调控骨髓造血干细胞归巢、调节干/前体细胞定向迁移至靶器官促进受损组织器官再生的病理生理过程中发挥着重要的作用。本文就SDF-1/CXCR4轴在成体干细胞迁移中的作用作简要综述。 Stromal cell derived factor-1 （SDF-1） is a potent chemoattractant for stem/progenitor cells, which can activate the CXCR4 receptor expressed in a variety of stem/progenitor cells, and this signaling results in diverse biological effects. SDF-1/CXCR4 axis plays an important role in stem/progenitor cell chemotaxis and homing in bone marrow and damaged tissues. This review summarized the roles of SDF-1/ CXCR4 in adult stem cell migration.
作者 张谊 李世荣 曹川 郑红
机构地区 第三军医大学附属西南医院整形外科 第三军医大学附属西南医院综合实验研究中心
出处 《免疫学杂志》 CAS CSCD 北大核心 2008年第2期243-246,共4页 Immunological Journal
关键词 基质细胞衍生因子 干细胞 迁移 Stromal cell-derived factor-1 Stem cell Migration
分类号 R329 [医药卫生—人体解剖和组织胚胎学]
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参考文献30

  • 1Imitola J, Racldassi K, Park KI. Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1 /CXC chemokine receptor 4 pathway [J]. PNAS, 2004, 1(52):18 117- 18 122.
  • 2Kucia M, Dawn B, Hunt G, et al. Cells expressing early cardiac markers reside in the bone marrow and are mobilized into the peripheral blood after myocardial infarction [ J ]. Circulation Research, 2004,95(5) : 1 191 - 1 205.
  • 3Vasyutina E, Stebler J, Brand Saberi B, et al. CXCR4 and Gab cooperate to control the development of migrating muscle progenitor cells [ J ]. Genes Development, 2005, 19 (6) : 2 187-2 198.
  • 4Aiuti A, Webb IJ, Bleul C, et al . The chemokine SDF-1 is a chemoattractant for human CD34^+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34^+ progenitors to periph2 eral blood [ J ].J Exp Med, 1997, 185(1):111 - 120.
  • 5Zou YR, Kottmann AH, KurodaM, et al. Function of the ehemokine receptor CXCR4 in haematopoiesis and in cerebellar development [ J ]. Nature, 1998, 393 ( 6685 ) : 595 - 599.
  • 6Ratajczak MZ, Majka M, Kucia M, et al. Expression of functional CXCR4 by muscle satellite cells and secretion of SDF-1 by muscle-derived fibroblasts is associated with the presence of both muscle progenitors in bone marrow and hematopoietic stem /progenitor cells in muscles [ J]. Stem Cells, 2003, 21(3): 363-371.
  • 7Yamaguchi J, Kusano KF, Masuo O, et al. Stromal cell- derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization [J]. Circulation, 2(D3, 107(9) : 1 322 - 1 328.
  • 8Ratajczak MZ, Kucia M, Reca R, et al. Stem cell plasticity revisited: CXCR4-positive cells expressing mRNA for early muscle, liver and neural cells 'hide out' in the bone marrow [J]. Leukemia, 2004, 18(1): 29-40.
  • 9KorblingM, Estrov Z. Adult stem cells for tissue repair-a new therapeutic concept [ J ]. N Engl J med, 2003, 349 (6): 570- 582.
  • 10Lapidot T, Kollet O. The essential roles of the chemokine SDF-1 and its receptor CXCR4 in human stem cell homing and repopulation of transplanted immune-deficient NOD/SCID andNOD/SCID/B2m (null) mice [J]. Leukemia, 2002, 16(10) : 1 992 - 2 003.

二级参考文献10

  • 1Gage FH. Mammalian neural stem cells. Science,2000,287(25):1433-1441.
  • 2Bjorklund A, Lindvall O. Self-repair in the brain. Nature,2000,405(22):892-895.
  • 3Reynolds BA, Weiss S. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science,1992,255:1707-1710.
  • 4Krum JM, Rosenstein JM. Transient coexpression of nestin, GFAP and vascular endothelial growth factor in mature reactive astroglia following neural grafting or brain wounds. Exp Neurol, 1999,160:348-360.
  • 5Gao W, Wen R, Li F, et al. Mechanical injury increases bFGF and CNTE mRNA expression in the mouse retina. Exp Eye Res, 1997,65(2):241.
  • 6Ono K, Tomasiwicz H, Magnuson T, et al. N-CAM mutation inhibits tangential neuronal migration and is phenocopied by enzymatic removal of polysialated acid. Neuron, 1994,13:595.
  • 7Soares HD, Hicks RR, Smith DH, et al. Inflammatory leukocyte recruitment and diffuse neuronal degeneration are separate pathological processes resulting from traumatic brain injury. J Neurosci,1995,15:8223-8233.
  • 8Guilian D, Woodward J, Young DG, et al. Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization. J Neurosci, 1988,8:1485-2490.
  • 9Carbonell WS, Grady MS. Regional and temporal characterization of neuronal, glial and axonal reponse after traumatic brain injury in the mouse. Acta Neuropathol, 1999,98:396-406.
  • 10王小平,王天佑,李力仙.一种制备大鼠液压性脑损伤的实验装置[J].中华实验外科杂志,1998,15(5):473-473. 被引量：7

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免疫学杂志
2008年 第2期

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