摘要
目的探讨胃炎饮对实验性胆汁反流性胃炎大鼠胃黏膜P物质(SP)含量的影响。方法采用自制反流液灌胃建立实验性胆汁反流性胃炎大鼠模型,以吗叮啉为对照,观察胃炎饮对实验性胆汁反流性胃炎大鼠胃黏膜病理组织学和胃黏膜SP含量的影响。结果模型组大鼠胃黏膜出现明显破损、脱落,黏膜下可见大量炎细胞浸润,大部分大鼠可见不典型增生和肠上皮化生,同时胃黏膜SP含量下降(P<0.01),与模型组比较,胃炎饮可明显改善实验性胆汁反流性胃炎大鼠胃黏膜病理组织学,并升高SP含量(P<0.05或P<0.01)。结论胃炎饮具有升高模型大鼠胃黏膜SP含量,促进胃蠕动,保护胃黏膜的作用。
Objective To observe the effect of Weiyanyin on Substance P（SP） in gastric mucosa of experiment bile reflux gastritis rats. Methods The model of experiment bile reflux gastritis was established by pared with Domperidone, the effect of Weiyanyin on pathological histological features and reflux gastritis rats was observed. Results The gastric mucosa of rats in model group was gavage of reflux liquid. Comthe mucosal SP content of bile damaged, and alopecia of gastric mucosa, and infiltration of a large number of inflammatory cells could be seen. In most of the rats in the model group, atypical hyperplasia and intestinal metaplasia were present. Meanwhile, the content of SP was decreased （ P 〈 0. 01 ） . Compared with the model group, Weiyanyin could improve pathological histological features in experimental bile reflux gastritis rats, and increase the content of SP （ P 〈 0. 05 or P 〈 0. 01 ）. Conclusion Weiyanyin could increase the content of SP, improve gastric peristaltic function of stomach and protect gastric mucosa of experimental bile reflux gastritis rats effectively.
出处
《中药新药与临床药理》
CAS
CSCD
2008年第2期94-97,共4页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
河北省中医药管理局科学研究计划项目(2007016)
