P185基因在喉鳞癌中的表达及其临床意义

Expression of P185 gene in laryngeal squamous cell carcinoma and its clinical significance

目的探讨P185基因在喉鳞癌组织中的表达及其临床意义。方法采用原位杂交方法检测49例喉鳞癌组织、19例声带息肉、12例癌旁增生组织及8例非典型增生组织中P185基因的表达情况。结果喉鳞癌组织中44例P185基因呈阳性表达,定位于胞浆。在声带息肉、癌旁增生组织及非典型增生组织中P185基因的阳性表达例数分别为0,4,5例,经统计学分析,喉鳞癌组织中P185基因的表达显著高于声带息肉、癌旁增生组织及非典型增生组织(P均<0.01),与喉鳞癌的临床分型分期,性别无相关性(P均>0.05)。结论喉鳞癌组织中P185基因呈高表达,提示P185基因可能参与调控了喉鳞癌的发生过程,且与喉癌的临床分期分型无关。

Objective To explore the relationship between the expression of P185 gene in laryngeal squamous cell carcinoma （ LSCC ） and its clinical significance. Methods In situ hybridization histochemical method was used to detect the expression of P185 in 49 LSCC tissues, 19 vocal cord polyps ,12 paracancerous tissues and 8 atypical hyperplasia tissues. Results Positive expression of P185 was seen in 44 cases of LSCC, which were located in cytoplasm. Positive P185 expression in the vocal cord polyps tissues, paracancerous tissues and atypical hyperplasis tissues were seen in 0, 4 and 5 cases respectively. The expression of P185 in the carcinoma tissues was significantly higher than that in the vocal cord polyps, paracancerous and atypical hyperplasia tissues （P 〈 0.01 ）, but was not correlated with gender or the clinical staglng/typing of LSCC （P 〉 0.05 ）. Conclusions There was high-expression of P185 in LSCC, which suggested that P185 may participate in the regulation of tumorigenesis in LSCC.