冠状动脉造影病变程度与高敏C反应蛋白等心血管疾病危险因素的关系

Relationship between intensity of coronary artery angiographic lesions and high-sensitivity C-reactive protein or other cardiovascular risk factors

目的探讨冠状动脉造影病变程度与血清高敏C反应蛋白(hs-CRP)水平的关系。方法选择2003年2月至2006年8月,笔者医院心内科收治的临床可疑冠心病患者148例,年龄30～81(61.92±10.23)岁,其中男性103例,女性45例。根据冠状动脉造影结果将148例患者分为冠心病组(102例)和对照组(46例),并根据冠状动脉病变程度将冠心病组分为单支病变亚组、双支病变亚组和三支病变亚组,分别测定各组颈动脉斑块形成情况、血清hs-CRP、血尿酸、血糖和血脂水平。详细记录各组患者血压、吸烟史、高血压和糖尿病史。对冠心病组与对照组hs-CRP水平及其他危险因素进行分析比较,对hs-CRP水平与冠状动脉病变的关系进行多元回归分析。结果①冠心病组血清hs-CRP水平显著高于对照组(P<0.05);②双支和三支病变组血清hs-CRP水平显著高于单支病变组(P<0.05)。结论血清hs-CRP水平不仅是冠心病的独立危险因素,而且是反映冠状动脉造影结果严重程度的敏感指标。

Objective To investigate the relationship between the intensity of coronary artery lesions and the level of high- sensitivity C-reactive protein （hs-CRP）. Methods A total of 148 suspective patients （aged 30 - 81 years,male 103,female 45） were performed coronary artery angiography and then divided into coronary heart disease group （CHD group ,n = 102） and non- coronary heart disease group （control group,n = 46）. According to the intensity of coronary artery disorder,CHD group was subdivided into 3 subgroupssingle branch lesion, 2 branch lesions and 3 branch lesions. The levels of hs-CRP and serum uric acid, glucose and cholesterol were measured and the blood pressure, history of cigarette smoking, hypertension and diabetes were recorded in each group. Results ①Thelevelofhs-CRPinCHDgroupwasmarkedlyhigherthanthatinNCHDgroup （P〈0.05）; ②The levels of hs-CRP in 2 branch and 3 branch lesions subgroup were markedly higher than that in single branch subgroup （P 〈 0.05）.Conclusion Serum hs-CRP is not only a strong independent risk factor of CHD,but also a sensitive index of coronary artery angiographic lesion intensity.