期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

^(131)I-chTNT放射免疫治疗晚期肺癌的研究进展 被引量：5

Advance in ^(131)I-chTNT radioimmunotherapy for advanced lung cancer
下载PDF
导出
摘要 近年来靶向治疗、治疗性抗体、放射免疫治疗等新的治疗手段的应用,使肿瘤综合治疗的疗效进一步提高,患者的生活质量得到明显改善。针对恶性肿瘤变性坏死细胞的[^(131)I]-肿瘤细胞核人鼠嵌合单克隆抗体(^(131)I-chTNT)已开始在临床应用,这是全球首个肺癌放射免疫治疗药物。^(131)I-chTNT对于放射治疗、化学药物治疗失败的晚期肺癌患者具有明显的疗效,并且其适用于所有的晚期实体瘤患者,疗效不受肿瘤的生长部位和病理类型的限制。
作者 刘雪辉 谭建
机构地区 天津医科大学总医院核医学科
出处 《生物医学工程与临床》 CAS 2008年第2期159-162,共4页 Biomedical Engineering and Clinical Medicine
关键词 ^131I-CHTNT 放射免疫治疗 肺癌 靶向
分类号 R734.2 [医药卫生—肿瘤]
  • 相关文献

参考文献20

  • 1程翔,童莉.肺癌生物治疗研究进展[J].现代中西医结合杂志,2006,15(6):829-831. 被引量：4
  • 2甄永苏.肿瘤的靶向治疗[J].国外医学（肿瘤学分册）,2002,29(5):323-326. 被引量：13
  • 3Tijink BM ,Neri D ,Leemans CR ,et al. Radioimmunotherapy of head and neck cancer xenografts using ^131I-labeled antibody L19-SIP for selective targeting of tumor vasculature [J]. Nucl Med, 2006,47(7) : 1127-1135.
  • 4Chen ZN, Mi L, Xu J, et al. Targeting radioimmunotherapy of hepatocellular carcinoma with iodine(^131I) metuximab injection: clinical phase Ⅰ /Ⅱ trials [J]. Int Radiat Oncol Biol Phys, 2006,65(2): 435-444.
  • 5Borghaei H,Schilder RJ. Safety and efficacy of radioimmunotherapy with yttrium 90 ibritumomab tiuxetan (Zevalin)[J]. Semin Nucl Med,2004,34 (1 Suppl 1):4-9.
  • 6DeMonaco NA, McCarty KS Jr,Joyce J ,et al. Focal radiation fibrosis after radioimmunotherapy for follicular non-Hodgkin lymphoma[J]. Clin Lymphoma Myeloma, 2007,7(5) : 369-372.
  • 7Hornick JL,Sharifi J,Khawli LA,et al. A new chemically modified chimeric TNT-3 monoclonal antibody directed against DNA for the radioimmunotherapy of solid tumors [J]. Cancer Biother Radiopharm, 1998,13 (4) : 255-268.
  • 8丁勇,田嘉禾,杨武威,杨志,徐发良,张书文,陈英茂,关志伟.^(188)Re-CL58、^(131)I-chTNT放射免疫治疗的临床研究[J].中国肿瘤临床,2004,31(1):8-11. 被引量：8
  • 9Chen S, Yu L, Jiang C, et al. Pivotal study of iodine-131-labeled chimeric tumor necrosis treatment radioimmunotherapy in patients with advanced lung cancer [J]. J Clin Oncol,2005,23 (7):1538-1547.
  • 10Boerman OC,Koppe MJ,Postema EJ,et al. Radionuclide therapy of cancer with radiolabeled antibodies[J]. Anticancer Agents Med Chem,2007,7(3) : 335-343.

二级参考文献37

  • 1甄永苏,邵荣光,江敏,李军智,王耐勤,董志伟.抗癌抗生素C1027与单克隆抗体偶联物的抗肿瘤作用[J].中国肿瘤生物治疗杂志,1995,2(2):94-98. 被引量：7
  • 2熊小兵,黄悦,吕万良,张煊,张华,张强.RGD类似物修饰的阿霉素隐形脂质体的制备及体外细胞结合试验[J].药学学报,2005,40(12):1085-1090. 被引量：14
  • 3Ruotsalainen Tarja M,Mattson Karin.Interferon trials in small cell lung cancer at one institution:a comparison of results obtained before and after initiation of systematic treatment trials using IFN-alpha in combination with other modalities[J].J Interferon Cytokine Res,2002,22(2):165-171
  • 4Takashi Nishikawa,Rajagopal Ramesh,Anupama Munshi,et al.Adenovirus-mediated mda-7 (IL24) gene therapy suppresses angiogenesis and sensitizes NSCLC xenograft tumors to radiation[J].Mol Ther,2004,9(6):818-828
  • 5Luis E,Raez Peter,Cassileth,et al.O-152 Immunotherapy with gene-modified allogenic cells successfully induced CD8 T cell and clinical responses in patients with advanced non-small cell lung cancer (NSCLC)[J].Lung Cancer,2003,41(2):46-47
  • 6Kris MG,Natale RB,Herbst RS,et al.Efficacy of gefitinib,an inhibitor of the epidermal growth factor receptor tyrosine kinase,in symptomatic patients with non-small cell lung cancer:a randomized trial[J].JAMA,2003,290(16):2149-2158
  • 7Govindan,R.Cetuximab in advanced non-small cell lung cancer[J].Clin Cancer Res,2004,10(12Pt2):4241-4244
  • 8Nemunaitis J,Nemunaitis J.Granulocyte-macrophage colony-stimulating factor gene-transfected autologous tumor cell vaccine:focus correction to fcous on non-small cell lung cancer[J].Clin Lung Cancer,2003,5(3):148-157
  • 9Swisher S G,Roth J A,Komaki R,et al.Induction of p53-regulated genes and tumor regression in lung cancer patients after intratumoral delivery of adenoviral p53 (INGN 201) and radiation therapy[J].Clin Cancer Res,2003,9(1):93-101
  • 10Alain G Zeimet,Christian Marth.Why did p53 gene therapy fail in ovarian cancer[J]? The Lancet Oncology,2003,4(7):415-422

共引文献29

同被引文献44

引证文献5

二级引证文献13

生物医学工程与临床
2008年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部