依利替康联合5-氟尿嘧啶、亚叶酸钙治疗晚期大肠癌

Clinical Observation of Combined CPT-11 Plus 5-Fluorouracil、Leucovorin in Treatment of Advanced Colorectal Cancers

目的探讨依利替康(CPT-11)联合5-氟尿嘧啶(5-FU)、亚叶酸钙(CF)治疗晚期大肠癌的疗效及不良反应。方法24例晚期大肠癌患者采用CPT-11 150 mg/m2加入0.9%氯化纳注射液250 mL中静脉滴注,第1天;5-FU 400 mg/m2静脉推注,再用5-FU 600 mg/m2通过全自动注药泵持续静脉输注22 h,第1、2天;CF200 mg/m2加入5%葡萄糖注射液250 mL中静脉滴注,第1、2天。14 d为1个周期,3周为1个疗程。结果24例患者中,完全缓解(CR)1例,部分缓解(CR)7例,稳定(SD)10例,进展(PD)6例,总有效率为33.3%。不良反应主要有:迟发性腹泻12例和中性粒细胞减少17例。结论CPT-11联合5-FU、CF方案治疗晚期大肠癌患者有较好的疗效,不良反应少,值得临床应用。

Objective To observe the effect and toxicity of the regimen of CPT-11 combined with fluorouracil and leucovorin in the treatment of advanced colorectal Cancer. Methods CPT-11 150 mg/m^2 and 0. 9% NaCl 250 mL ivgtt dl 5-FU 400 mg/m^2 iv bolus, Following 5-FU 600 mg/m^2 ivgtt 22 h dl,d2;CF 200 mg/m^2 and 5 % 60GS 250 mL ivgtt 2 h dl,d2;two weeks as one cycle,efficacy and toxicity were evaluated at three cycles. Results Twenty-four cases could be evaluated. CR 1 cases;PR 7 cases,SD 10 cases,PD 6 cases. The overall response rate was 33.3%, The main toxicity were delayed diarrhea,marrow suppression in 12 cases and vomiting in 17 cases. Conclusion The result shows that the chemotherapy of CPT-11 combined fluorouracil and leucororin is effective and tolerable in advanced colorectal cancer. It is good for generalizing.