摘要
目的:观察乙型肝炎病毒相关性膜性肾病(hepatitis B virus associated membranous nephropathy,HBV-MN)肾小球足细胞Nephrin的表达,以探讨其发病意义。方法:经肾活检病理检查确诊的HBV-MN患者8例及原发性膜性肾病(IMN)患者5例,采用间接免疫荧光激光共聚焦显微镜观察足细胞Nephrin表达的变化。结果:HBV-MN组肾小球内Nephrin荧光强度较IMN组明显减弱,且部分节段有缺失。结论:肾小球足细胞裂孔膜蛋白Nephrin表达降低可能在HBV-MN发病中起一定的作用。
Objective： To study the expression changes of nephrin on podocyte in hepatitis B virus associated membranous nephropathy. Methods： Renal expressions of nephrin from the patients with hepatitis B virus associated membranous nephropathy （Group A, 8 cases） and idiopathic membranous nephropathy patients （Group B, 5 cases） were determined by indirect immunofluorescene histochemitry. Results： By indirect immunofluorescene histochemitry, glomerular expressions of nephrin were more significantly decreased in Group A than that in Group B. Conclusion： The changes of the expression of nephrin may play a pathogenetic role in hepatitis B virus associated membranous nephropathy.
出处
《交通医学》
2008年第1期4-5,8,共3页
Medical Journal of Communications
基金
国家自然科学基金(30670986)
江苏省自然科学基金(BK2006059)
