摘要
A new dexamethasone derivative of 9-fluoro-16α-methyl-11,17-dihydroxy-3-oxo-1,4-androsladiene-17β-carboxylic acid from dexamethasone is synthesized by oxidization with periodic acid. The physicochemical property of the new derivative is identified with routine methods. Its structure is characterized by 1H NMR,13C NMR and ESI-MS spectra. The effect of the new derivative on K562 cell proliferation was detected by MTT, as well as the cell cycle by flow cytometry.The result show that the dexamethasone derivative had anti-tumor activities of K562 cell proliferation inhibition and cell cycle arresting from G0/G1 to S phase.
A new dexamethasone derivative of 9 - fluoro - 16α - methyl - 11,17 - dihydroxy - 3 - oxo - 1,4 - androsladiene - 17β - carboxylic acid from dexamethasone is synthesized by oxidization with periodic acid. The physicochemical property of the new derivative is identified with routine methods. Its structure is characterized by ^1 H NMR,^13C NMR and ESI - MS spectra. The effect of the new derivative on K562 cell proliferation was detected by MTT, as well as the cell cycle by flow cytometry. The result show that the dexamethasone derivative had anti - tumor activities of K562 cell proliferation inhibition and cell cycle arresting from G0/ G1 to S phase.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2008年第3期341-344,共4页
Chemical Research and Application
基金
国家自然科学基金(30300449)资助项目
国家中医药管理局(02-03ZP52)资助项目
关键词
地塞米松衍生物
合成
抗肿瘤活性
dexamethasone derivative
synthesis
anti - tumor activity
