摘要
6-Aminoindole (3) is obtained from the reaction of substituted 2,4-dinitrotoluene(1) condensation with N,N-dimethylformamide dimethyl acetal (DMFDMA) and reduction with Fe/HAc. Compounds 5(a^d) are synthesized from (3) reaction with POC13/DMF, PhCOCl/AgNO3 and thiourea respectively. The structures of 5(a^d) are analyzed and established by MS, IR and 1H NMR spectra. The antibacterial activities of the compounds have been tested against three kinds of bacteria. The results show that the compounds possess different bacteriactivities.
6-Aminoindole （3） is obtained from the reaction of substituted 2,4-dinitrotoluene（1） condensation with N,N-dimethylformamide dimethyl acetal （DMFDMA） and reduction with Fe/HAc. Compounds 5 （ a - d） are synthesized from （3） reaction with POCl3/DMF, PhCOCl/AgNO3and thiourea respectively. The structures of 5 （a- d） are analyzed and established by MS, IR and ^1 H NMR spectra. The antibacterial activities of the compounds have been tested against three kinds of bacteria. The results show that the compounds possess different bacteriactivities.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2008年第3期348-351,共4页
Chemical Research and Application
基金
西南民族大学人才引进项目(234688)资助
