转录调节因子ETS-1在血管生成中的作用

Role of transcription regulatory factor ETS-1 in angiogenesis

学术背景:ETS-1是ETS家族转录因子的第一个亚族,在血管生成中起重要的调控作用。近年研究显示ETS-1对血管内皮细胞的凋亡也有重要的调控作用,在血管生成开始,ETS-1决定局部内皮细胞的凋亡。目的:总结血管生长因子ETS-1在血管生成及细胞凋亡中的作用和研究进展。检索策略:由该论文的研究人员应用计算机检索PubMed,Sciencedirect,Ovid数据库1990-01/2007-09的相关文献,检索词为"ETS-1,angiogenesis,apoptosis,osteoblast,osteoclast",限定文章语言种类为English。同时计算机检索中国期刊全文数据库、万方数据库2000-01/2007-06期间的相关文章,检索词为"ETS-1,血管生成,细胞凋亡,内皮细胞",限定文章语言种类为中文。共检索到128篇文献,对资料进行初审,纳入标准:①与ETS-1在血管生成和细胞凋亡密切相关。②同一领域选择近期发表或在权威杂志上发表的文章。排除标准:重复性研究。文献评价:文献的来源主要是EST-1在血管生成和细胞凋亡方面的试验研究。所选用的31篇文献中,2篇为综述,29为临床或基础实验研究。资料综合:①正畸牙齿移动中,牙槽骨的改建是骨吸收和新骨形成的动态平衡过程。这一过程机制复杂,受多种因子的调节。②在众多正调控因子中ETS-1是主要的促血管形成因子,在血管形成中起重要作用。③研究表明,4种典型的血管生长因子:酸性成纤维细胞生长因子,碱性成纤维细胞生长因子,血管内皮生长因子和表皮生长因子能够诱导血管内皮细胞的ETS-1的表达,ETS-1通过诱导血管生成的相关因子如基质金属蛋白酶和整合素β3的表达促进血管生成。④关于ETS-1在调控血管生成方面取得很大的进展,但仍存在许多问题,如ETS-1如何精确的调控血管生成,如何精确的调节细胞凋亡的基因表达等。结论:作为血管生成和细胞凋亡的一种重要调节因子,ETS-1对血管的生成和细胞凋亡具有重要的调节作用。

BACKGROUND： ETS-1, the first subgroup in the ETS family transcription factor, plays a key role in angiogenesis. Recent studies demonstrate that ETS-1 also has the important regulative functions in apoptosis of vascular endothelial cells. When the blood vessel begins to form, ETS-1 decides the apoptosis of partial endothelial cells. OBJECTIVE： To summarize the function and the research progress of vascular growth factor ETS-1 in angiogenesis and apoptosis. RETRIEVAL STRATEGY： A computer-based search in Pubmed, Sciencedirect and Ovid database was underwent to identify the articles from January 1990 to September 2007, with the key word ＂ETS-1, angiogenesis, apoptosis, osteoblast, osteoclast＂ in English. Simultaneously, Chinese Journal Full-text Database and Wanfang database were retrieved for the related articles from January 2000 to June 2007, with the key word ＂ETS-1, angiogenesis, apoptosis, endothelial cell＂ in Chinese. Altogether 128 articles were collected and carried on the first examination. Inclusive criteria： ①The articles closely correlated with ETS- 1 in angiogenesis and apoptosis.②The articles published recently or in the authoritative magazine were chose for the identical domain. Exclusive criteria： Duplicated researches. LITERATURE EVALUATION： The articles were mainly the experimental study of EST-1 in angiogenesis and apoptosis. Among 31 selected articles, 2 were reviews while other 29 for clinical or basic experimental studies. DATA SYNTHESIS：①When orthodontic tooth moves, alveolar bone rebuilding is the dynamical equilibrium process between bone absorption and new bone formation. This process mechanism is complex and adjusted by many kinds of factors.②Among numerous regulatory factors, ETS-1 is the dominant factor and has important effect on angiogenesis.③The research indicates, four kinds of typical vascular growth factors （acid fibroblast growth factor, basic fibroblast growth factor, vascular endothelial growth factor and epidermal growth factor） can induce the ETS-l expression, and ETS-1 promotes vessel production through inducing the expressions of the related factors with angiogenesis, such as matrix metalloproteinase and integrin β3.④Many progresses have been achieved in the regulatory effect of ETS-1 in angiogenesis, but it still has many problems, such as how the ETS-I precisely regulate angiogenesis, how the ETS-1 precisely adjust apoptosis in gene expression and so on. CONCLUSION： As a kind of important regulatory factors, ETS-1 has important regulatory effects on angiogenesis and apoptosis.