原发性肾病综合征患者D-Ⅱ聚体检测的临床意义

Effects of D-dimer on primary nephrotic syndrome

目的探讨D-Ⅱ聚体(D-dimer)含量评价肾病综合征患者凝血、纤溶活性的临床意义。方法采用定量酶联免疫吸附法测定不同病理类型的肾病综合征87例,以及正常对照组30例患者内D-Ⅱ聚体含量,比较各组D-Ⅱ聚体含量。结果D-Ⅱ聚体阳性发生率和含量:各组肾病综合征患者均明显高于对照组,P<0.01;在各组肾病综合征患者中,膜性肾病组高于其他组,P<0.05。结论D-Ⅱ聚体增高显示肾病综合征患者体内有微血栓形成和溶解同时进行的活化血栓形成,需积极抗凝治疗。

Objective To observe the association between D-dimer and the thrombin active on nephrotic syndrome. Methods 87 patients were enrolled in the study group, and 30 peoples were enrolled in the normal control group, compared the dose of D-dimer in two groups. Results The levels of D-dimer in patients with nephritic syndrome increased remarkably as compared with control group （ P 〈 0.01 ）, the levels in patients with membranous nephropathy also increased remarkably as compared with other nephropathy of nephritic syndrome （P 〈 0.05 ）. Conclusion D-dimer possibly play a role in the thrombin active on nephritic syndrome,they must be treated with anticogulant.