脑梗死患者高敏C反应蛋白水平变化的临床意义

Clinical signficance of high-sensitivity C-reactive protein measurement in cerebral infarction

目的探讨脑梗死(CI)患者血清高敏C反应蛋白(hs-CRP)水平与病情严重程度及预后的关系。方法采用胶乳增强免疫比浊法分别测定80例CI患者入院24h内(急性期组)和治疗2周后(恢复期组)的血清hs-CRP水平,选择年龄、性别相匹配的同期健康体检者80例作对照。观察不同大小梗死灶和不同神经功能缺损程度的CI患者血清hs-CRP水平变化。结果急性期组和恢复期组的血清hs-CRP水平明显高于对照组(P均<0.001),且急性期组血清hs-CRP水平明显高于恢复期组(P<0.01);大面积梗死CI患者hs-CRP水平明显高于小面积CI患者(均P<0.01);神经功能缺损程度越严重,hs-CRP水平越高(P均<0.01)。结论血清hs-CRP水平反映了CI患者的梗死面积和神经功能缺损程度,可用于CI患者病情的判断和预后的评估。

Objective To investigate the correlation of serum high-sensitivity c-reactive protein （hs- CRP）and disease severity and prignosis in cerebral infarction （CI）. Methods The particle-enhanced immunoturbidimetric assay was used to measure the serum hs-CRP levels both in 80 CI cases within 24h at admission （acute stage group）and 2wk after treatment （recovery stage group）, as compared with those in 80 age-and gender-matched healthy controls,The hs-CRP level alterations were observed in varying infarction sizes and neurological deficits in CI patients. Results The hs-CRP levels were considerably higher in both the acute and recovery stage group than in the controlled group（P〈0.01）, and the hs-CRP level was substantially higher in the acute stage group than in the recovery group （P〈0.01）. The hs-CRP levels in CI patients with large infarction size were markedly higher as compared to minor infarction size,all P〈0.01. And the more severe the neurological deficits were, the higher the hs-CRP levels were, all P〈0.01. Conclusion Serum hs-CRP level can reflect the infarction size and neurological defect severity in CI patients,holding for condition judgement and prognosis assessment of them.