院内感染常见细菌分布及其药敏试验分析

NOSOCOMIAL INFECTION:COMMONLY-SEEN-BACTERIA DISTRIBUTION AND DRUG SENSITIVITY TEST

目的调查住院病人致病细菌菌群分布及药敏试验情况,以指导临床应用抗生素。方法对住院病人体液、分泌物标本进行细菌培养,共培养出12 400株常见致病细菌,对其进行细菌鉴定及药敏试验分析。结果12 400株细菌中,阴性杆菌占86.43%,不动杆菌占8.28%,大肠埃希菌占23.31%。药敏试验显示,常见致病细菌对亚胺培南的耐药率最低,对β-内酰胺类及喹诺酮类抗生素耐药率较前有明显增加。结论院内感染的致病菌以阴性杆菌为主,细菌耐药性明显增强。临床应严格控制抗生素的应用以降低细菌耐药性。

Objective To investigate microbial population of inpatient infection and their drug sensitivity in order to guide clinical use of antihiotics. Methods Samples of body fluid and secretion of hospitalized patients were cultured, in which, 12 400 pathogenic strains isolated and susceptibility test done. Results Of the 12 400 strains cultured, gram-negative bacilli accounted for 86.43;, Acinetobacter, 8.28%, and Escheriehia coli, 23.31%. The drug sensitivity showed that drug resistance rate to imipenem was the lowest, while the resistance to β-lactamase antibiotics and Quinolones increased markedly. Conclusion The pathogenic bacteria responsible for hospital-acquired infection are mostly gram-negative bacilli with obviously increasing drug resistance. Clinical application of antibiotics should be strictly controlled to reduce drug resistance of bacteria.