液相氧化间氯甲苯合成间氯苯甲酸

Synthesis of m-Chlorobenzoic Acid from m-Chlorotoluene by Liquid-phase Oxidation

在醋酸溶液中,醋酸钴为催化剂,以间氯甲苯、氧气为原料合成间氯苯甲酸,分别研究了反应温度、反应时间、原料配比、催化剂的用量等条件对合成反应的影响,确定了最佳工艺条件。该方法合成间氯苯甲酸的最适宜的操作条件是:反应温度为100℃、反应时间为12 h、n(间氯甲苯)∶n(醋酸)=1∶3、催化剂的用量为0.03 mol(相对于0.2 mol间氯甲苯)。间氯苯甲酸的收率可达到95.17%以上,间氯苯甲酸产品纯度99.5%。

In acetic acid and using cobaltous acetate as catalyst m-chlorobenzoic acid was synthesized by the reaction of m-chlorotoluene with oxygen. The effect of reaction temperature, reaction time, materials ratio and amount of catalyst on the synthesis was studied, and the proper reaction conditions were given as follows：reaction temperature, 100℃; reaction time, 12 h; n（m-chlorotoluene） ： n（acetic acid）=1： 3; amounts of catalyst, 0.03 mol（based 0.2 mol m-chlorotoluene）. The yield of m-chlorobenzoic acid reached 95.17%, and the purity of m-chlorobenzoic acid was 99.5%.