ZASP基因与扩张型心肌病

ZASP Gene and Dilated Cardiomyopathy

随着分子生物学技术的发展,对扩张型心肌病的分子遗传机制认识也在不断提高。ZASP(Z-band alternatively spliced PDZ-motif protein)基因即Z带选择性缝接PDZ基序蛋白基因,国外新近研究揭示了编码心肌肌小节Z带蛋白的ZASP基因突变对扩张型心肌病心肌细胞骨架成分构成及肌小节收缩功能的影响,但仍存在着一些不同的观点。现就ZASP基因的结构构成与导致扩张型心肌病的可能机制作一综述。

To follow the development of molecular biology, unceasing elevated recognition with dilated cardiomyopathy molecule genetic mechanism. ZASP gene is assumed Z-band alternatively spliced PDZ-motif protein. Recently, overseas study have revealed mutation of ZASP gene encoded Z-band protein of myocardial sarcomere, which has an effect on eystoskeleton component and sarcomere systolic function, however, some different views are existed. This article overviews construction of ZASP gene and mechanism of induced dilated cardiomyopathy.