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促红细胞生成素:新的心血管系统信号转导分子 被引量：4

Erythropoietin:A New Signal Transduction Molecule in Cardiovascular System
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摘要 传统认为促红细胞生成素(EPO)仅作用于造血细胞,最新研究表明它具有一些非造血效应,如在心肌缺血/再灌注时,有抗凋亡、抗炎等作用,认为它是心血管系统一个新的信号转导分子。其心血管保护作用无疑拓展了心血管疾病研究和治疗的新思路。临床上,EPO用于治疗心力衰竭或肾衰性贫血,不仅纠正贫血,而且改善心功能,提高患者的生活质量。但尚需进一步研究EPO心肌保护的分子机制,以阐明其在心血管系统中的治疗作用。 Although it was originally believed that erythropoietin （EPO） specifically acted on haematopoietical cells, recent evidence demonstrated several non-haematopoietical effects, such as, in myocardium ischemia-reperfusion, anti-apoptotic effects, suppressing inflammatory response and others. Recent studies showed that EPO is a new signal transduction molecule in the cardiovascular system. The cardiovascular protection of EPO has been recently discovered, opening new horizons in both clinical investigation and therapy. When anemia in patients with chronic heart failure or chronic renal failure is treated with erythropoietin, a significant improvement is obtained in both the anemia and cardiac function and the quality of life is increased. Further research into the molecular mechanisms of the effects on the heart will be necessary to delineate the benefits of EPO therapy in cardiovascular system.
作者 肖祥彬 马康华
机构地区 重庆医科大学附属第一医院心血管内科
出处 《心血管病学进展》 CAS 2008年第2期319-323,共5页 Advances in Cardiovascular Diseases
关键词 促红细胞生成素 心血管系统 erythropoietin cardiovascular system
分类号 R33 [医药卫生—人体生理学]
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参考文献29

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同被引文献35

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心血管病学进展
2008年 第2期

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