阿奇霉素与左氧氟沙星门诊治疗慢性支气管炎急性发作的对照研究

Comparison Study on Acute Exacerbations of Chronic Bronchitis Treated by Azithromycin and Levofloxacin in Outpatients

目的比较口服阿奇霉素与左氧氟沙星门诊治疗慢性支气管炎轻-中度急性发作的疗效和安全性。方法采用随机、开放、对照方法分为两组,共入选慢性支气管炎轻-中度急性发作门诊就诊者65例,阿奇霉素组32例(实际完成治疗30例),口服阿奇霉素500mg,1次/d,连续5d;左氧氟沙星组33例(实际完成治疗32例),口服左氧氟沙星500mg,1次/d,连续7d。结果治疗后第10天、第24天两组疗效比较差异无统计学意义(P>0.05)。两组临床症状改善所需时间、平均症状严重程度评分比较差异均无统计学意义(P>0.05)。两组细菌清除率、非典型病原体感染率间差异均无统计学意义(P>0.05)。两组不良反应发生率均较低,且差异无统计学意义(P>0.05)。结论口服阿奇霉素5d与口服左氧氟沙星7d门诊治疗慢性支气管炎轻-中度急性加重均有效且安全。

Objective To compare the safety and efficacy of oral azithromycin and levofloxacin in the treatment of out-patients with mild or medium acute exacerbations of chronic bronchitis （AECB）. Methods A randomized, open - label, con-trolled trial was conducted in sixty - five outpatients who had received a clinical diagnosis of AECB. Thirty two patients were treated with oral azithromycin, 500 mg qd for 5 days （acutely 30 patients completed the trial） , and 33 patients with oral levofloxacin, 500 mg qd for 7 days （ acutely 32 patients completed the trial）. Results Between the two groups, there was no statistic significance in effect on the10 th days and 24th days after treatment （ P 〉0. 05）, in both the necessary time for improvement of clinical symptoms and average score of symptom severity （ P 〉 0. 05 ） , and in bacterial eradication rate and infection rate of non - specific pathogens （ P 〉 0. 05 ）. The adverse effect rate in both group was lower, with no significant difference （ P 〉 0. 05 ）. Conclusion A 5 - day course of oral azithromycin and a 7 - day course of oral levofloxacin are both effective and safe in treatment of outpatients with mild or medium AECB.