应用超声评价阿魏酸钠对糖尿病患者肱动脉及微血管内皮功能的影响

Evaluation on effects of sodium ferulate on endothelium function of brachial artery and blood capillary in diabetic patients with ultrasonography

①目的探讨应用超声多普勒对评价阿魏酸钠(SF)治疗前后2型糖尿病(DM)患者血管内皮功能和血流动力学的变化及其意义。②方法观察组2型DM患者72例,正常对照组20例,超声测定观察组肱动脉内皮依赖性舒张功能(FMD)、内皮非依赖性舒张功能(NMD)、视网膜中央动脉(CRA)、收缩末期血流速度(PSV)、舒张末期血流速度(EDV)、阻力指数(RI)变化。观察组SF治疗1疗程后再次测定上述指标。③结果与正常组比较观察组FMD、NMD、PSV、EDV降低(P<0.01),RI增高(P<0.05)。SF治疗后除NMD外余变化有不同程度改善(P<0.05)。④结论SF对早期DM血管病变防治有临床应用价值,超声可作为早期评价DM血管病变进展和药物治疗有效性的简易,且可靠的检查手段。

Objective To observe the changes of blood vessel edothelial function and hemodynamics in type 2 diabetes mellitus（DM） treated by sodium ferulate（SH） with ultrasonography. Methods The flux modulated dilation（FMD） and nitroglycerine modulated dilation（NMD） of the brachial artery, peak systolic velocity（ PSV）, end diastolic velocity （EDV）and resistent index（RI） of the central retinal artery（CRA） were determined by doppler in treatment group of 72 cases＇type 2 diabetic patients and control group of 20 cases normal person, arid these indexes were determined after 1 period of treatment with SF. Results When compared with the control group, the FMD,NMD,PSV,EDV in treatment group were decreased（ P 〈 0.01 ）, while the RI was increased（ P 〈 0. 05） ; These indexes were improved except NMD after SF treatment. Conclusions SF can prevent and treat the vascular lesion of DM in early period; Ultrasonograph may be regarded as an easy and reliable method which can evaluate the progress of vascular lesion in DM and the efficacy of the drug treatment.