肾衰养真胶囊对腺嘌呤致CRF营养不良模型大鼠营养状态的影响

Effect of Shenshuai Yangzhen Capsule on malnutrition rats with chronic renal failure

目的:观察肾衰养真胶囊(黄芪、人参、当归、大黄等)对慢性肾衰竭(CRF)营养不良大鼠的营养状况的影响。方法:予0.5%腺嘌呤和4%酪蛋白混合饲料喂养制作CRF营养不良大鼠模型,将符合条件的随机分为模型组、肾衰养真胶囊组和开同组,同时设正常组。治疗4周后检测体重、白蛋白、血红蛋白、甘油三脂、总胆固醇、胰岛素样生长因子-1等指标的变化,进行光镜(HE、PAS染色)观察肾组织病理学改变。结果:8周末大鼠造模成功,治疗后肾衰养真胶囊组摄食量和体重显著增加,与模型组比较,白蛋白、血红蛋白、胰岛素样生长因子-1显著升高;肌酐、尿素氮、24 h尿蛋白显著下降,大鼠的肾组织病理形态明显改善。结论:肾衰养真胶囊可明显改善腺嘌呤致CRF营养不良模型大鼠的营养状况,对CRF营养不良模型大鼠有肾保护作用。

AIM ： To investigate the effects of Shenshuai Yangzhen Capsule on malnutrition rats with chronic renal failure（CRF）. METHODS ： Rats were fed with 0.5% adenine and 4% caseinum to make malnutrition in CRF models. Those consistents with malnutrition of CRF condition were randomized into CRF control group, Ketosteril group Shenshuai Yangzhen Capsule group, and normal control group, after treatment for 4 weeks as indicated. The blood parameters, like blood serum albumin（ALB）, type-1 insulin like growth factor（ IGF-1 ）, total cholesterol （ TC ）, triglyeride（ TG）, urea nitrogen （ BUN）, serum creatinine （ Scr）, haemoglobin （ Hb）, 24 hour Urineprotein （24 hUpr） and weight were determined, nephrotic tissue was observed by microscope（ HE and PAS included）. RESULTS： Malnutrition situation in CRF rats appeared at the end of 8 weeks. After treatment for 4 weeks, foodintake and weight in Shenshuai Yangzhen Capsule group were higher significantly compared with those in CRF control group, blood serum BUN ,SCr and 24 hUpr in Shenshuai Yangzhen Capsule group decreased significantly while substantially blood serum ALB, Hb, IGF-1, TC, TG increased. Pathological change in Shenshuai Yangzhen Capsule group meliorated significantly after being treated. CONCLUSION： Shenshuai Yangzhen Capsule has possible effect on improving malnutrition in rats with renal insufficiency.