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偕二膦酸类化合物的合成 被引量:2

Synthesis of bisphosphonic analogues
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作者 张勇 陈虹
出处 《武警医学院学报》 CAS 2008年第3期247-249,252,共4页 Acta Academiae Medicinae CPAPF
基金 国家自然科学基金资助项目(30371682)
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参考文献20

  • 1Fleisch H, Russell RGG, Straumann F. Effect of pyrophosphate on hydroxyapatite and its implications in calcium homeostasis [J]. Nature, 1966, 212 (5065) : 901 - 903.
  • 2Fleisch H, Russcll RGG, Francis MD. Diphosphonates inhibit formation of calcium phosphate crystals in vitro and pathological calcification in vivo [J]. Science, 1969, 165 (3899): 1262-1264.
  • 3王军波,谢毓元.双膦酸作为骨靶向载体治疗骨质疏松症的研究进展[J].药学进展,2004,28(7):294-299. 被引量:4
  • 4吴勇,翁玲玲,郑虎.功能化偕二膦酸酯的合成[J].中国药物化学杂志,1995,5(4):254-257. 被引量:7
  • 5许爱东,林吉茂.亚甲基双膦酸四异丙基酯的制备[J].山东化工,2002,31(1):7-8. 被引量:4
  • 6Vepslinen J, Nupponen H, Pohjala E, et al . Bisphosphonic compounds: Part3. Preparation and didentification of tetraalkyl-methylene- and (a- Halomethylene ) bisphosphonates by mass spectrometry, NMR spectrometry and X- raycrystallography [J]. Chem Soc Perkin Trans, 1992, 2: 835- 842.
  • 7Fitch SJ, Moedritier KJ. [Hydroxy (aryl) methylene] diphosphonic acids, a class of drugs in bone pathology treatments, crystallize as head - to - head dimers [J]. Chem Soc, 1962, 84: 1876- 1879.
  • 8Grifiths DV, Hughes MJ. The synthesis of 1 - amino - 2- hydroxy-and2- amino-1-hydroxy-sbs-tiuted ethylene - 1, 1 - bisphosphonie acids and their N-methylated derivatives [J]. Tetrahedro-n, 1997, 53 (52): 17815-17822.
  • 9Ruel R, Young RN, Bouvier JP. Kieczykowski Gerard, R. WO 9633199, 1996 [Chem. bstr. 1997, 126, 8300].
  • 10Yokomatsu T, Yoshida Y, Nakabayashi N. Simple and efficient method for preparation of conformationally constrained aminomethylene gem-diphosphonate derivatives via Beckmann rearrangement [J]. Org Chem, 1994, 59 (24): 7562-7564.

二级参考文献47

  • 1朱传方,李中华,孙亚杰.烃基氨基二甲撑基膦酸的合成及其阻垢和缓蚀性能研究[J].化学通报,1995(11):29-30. 被引量:2
  • 2吴勇,翁玲玲,郑虎.功能化偕二膦酸酯的合成[J].中国药物化学杂志,1995,5(4):254-257. 被引量:7
  • 3陈卫民,徐继红.依替膦酸二钠的合成[J].中国医药工业杂志,1996,27(7):296-297. 被引量:4
  • 4俞雄,张秀平.双膦酸类药物研究进展[J].中国医药工业杂志,1997,28(3):110-114. 被引量:8
  • 5Bohacek RS, Dalarno DC, Hatada M, et al. X - ray structure of citrate botmd to src SH2 leads to a high-affinity,bone-targeted src SH2 inhlbitor[J]. J Med Chem, 2001,44(5) :660.
  • 6Sturtz G, Voisin P. Preparation of gem - diphosphonates oamlogs of metrotrexate as antitumor agents[P]. PCT Int Appl WO, 1988-06 -158.
  • 7Duschinsky R, Pleven E. The synthesis of 5 - fluoropyrimidines[J]. J Am Chem Soc, 1957,79:4559.
  • 8Degenhardt, Charles R, Burdsall, et al. Synthesis of ethenylidenebis(phosphonic acid ) and its tetraalkyl esters [J]. J Org Chem, 1986,51:3488.
  • 9Kaqreisky Marat, Padioukova Nelly, Mikhailov Sergey, et al. Bisphosphonate enujugates and methods of making and using the same[P].US,2000-06-214.812.
  • 10Bauss F, Esswein A, Reiff K, et al. Effect of 17beta-estradiol-bisphosphonate conjugates, potential bone-seeking estrogen pro-drugs, on 17beta-estradiol serum kinetics and bone mass in rats[J]. Calcif Tissue Int, 1996, 59(3):168-173.

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