C-erbB-2在贲门癌中的扩增及其临床意义

Amplification of Oncogene C-erbB-2 in Gastric Cardia Adenocarcinoma and Its Clinical Significance

目的:探讨贲门癌C-erbB-2癌基因扩增情况及其临床意义。方法:应用差别PCR技术检测32例贲门癌C-erbB-2癌基因扩增。结果:贲门腺癌C-erbB-2扩增率为50%;贲门癌C-erbB-2基因扩增与组织学分化程度、浸润程度均无关(P>0.05),与淋巴结转移有关(P<0.05)。结论:C-erbB-2癌基因扩增与贲门癌发生有密切关系,原癌基因C-erbB-2扩增可作为贲门癌淋巴结转移的生物学标志。

Objective：To explore the amplication of C -erbB -2 oncogene in Gastric cardia adenocarcinoma（GCA） and its clinical significance. Methods ：Oncogene C -erbB -2 amplification was examined by differential polymerase chain reaction in 32 cases of GCA. Results：16 out of 32 cases of GCA were found to have C -erbB-2 amplification. C -erbB -2 amplification in GCA was not correlated to histology differentiation and invasion degrees, but to lymph node metastasis. Conclusion： These results suggest that there is a close relationship between amplification of C - erbB - 2 and GCA, and amplification of C - erbB - 2 may be a biological marker for lymphatic matastasis in the patients with GCA.