人脑运动皮层功能磁共振成像研究

Investigation of the Human Brain Motor Cortex by Functional Magnetic Resonance Imaging

目的采用功能用磁共振成像(fMRI)回波平面(EPI)技术,研究人脑运动皮质血氧水平依赖(BOLD)的功能磁共振成像。方法27名正常健康志愿者,右手挤压橡皮圈,在运动和静止两种对比条件下,采集运动皮层的回波平面图像(BOLD-fMRI)。分析运动状态和非运动状态信号对比的脑功能图像。结果fMRI图像显示运动刺激下脑功能活动激活区主要位于对侧感觉运动皮质区、辅助运动区等。结论fMRI可用于研究活体人脑各功能区的活动,fMRI可对运动刺激下的人脑运动皮质进行初步定位。

Objective To explore functional magnetic resonance imaging （fMRI）of motor cortex by using echo planar imaging （EPI） and blood oxygenation level dependent （BOLD）contrast. Methods Twenty-seven healthy volunteers were included in this experiment. Motor stimulation was induced by repetitive pressing the rubber roll of right hand of the volunteers. The echo planar images of the motor cortex were acquired at motion stimulation and rest phases. T-test analysis was used to statistically generate the activation map. Results The activation areas were found in contralateral sensorimotor area,bilateral supplementary motor area and so on. Conclusion fMRI could be used to study human functional cortex. A preliminary location of the motor cortex can be acquired through motor stimulation.