氟化钠对去卵巢大鼠骨元素代谢的影响

The Effect of Sodium Fluoride on Bone Minerial Element Metabolism in Ovariectomized Rats

用测定骨元素含量的方法,分析氟化钠(NaF)对去卵巢大鼠骨元素代谢的影响。将健康4月龄雌性SD大鼠24只,用抽签法随机分成4组:正常对照组、假去卵巢组、去卵巢组、去卵巢+NaF组。去卵巢+NaF组大鼠于去卵巢手术后第2 d开始给予NaF溶液灌胃,1 mg/(kg.BW),1次/d,持续11周。结果表明,去卵巢大鼠骨Ca、、Mg、Zn、Co、Mn等元素含量显著降低,骨P含量增加。NaF可使去卵巢大鼠降低的骨Ca、S、Mg、Co、Mn等元素含量回升,骨P含量回降。NaF可纠正去卵巢大鼠所致的骨元素代谢紊乱。

To investigate the influence of sodium fluoride （NaF）on bone mineral element metabolism in ovariectomized rats, 24 female Sprague- Dawley （SD） rats were divided randomly into 4 groups： normal control, sham ovariectomy, ovariectomy （ OVX）, NaF intake after OVX. The results show that（1）Ca, S,Mg,Zn, Co, Mnreduce and P increases in the bone of the OVX rats. （2） NaF opposes the changes of Ca, S, Mg, Co, Mn and P in the bone of the OVX rats. It concluded NaF opposes the changes of Ca, S, Mg, Co, Mn and P in the bone of the OVX rats.