溴代二羟基硝基二苯醚类化合物的合成与抑菌活性研究

Synthesis and Antimicrobial Activities of Brominated Dihydroxy Nitro Diphenyl Ethers

综合考虑二苯醚类杀菌剂结构与活性关系的前期研究结果,以双羟基二苯醚为原料,经酸酐保护、硝化、去保护得到含硝基的双羟基二苯醚,再经过溴代反应合成了7个新的溴代2,2'-,2,4'-和4,4'-二羟基硝基二苯醚;所有这些化合物的结构均经1HNMR,MS,IR和元素分析所证实;并检测了合成的溴代二羟基硝基二苯醚化合物对两种有害菌的抑菌活性,结果表明:它们对所测试菌种具有优良的抑制效果,其中3个化合物在质量分数为5×10-6的浓度下抑菌率超过100%,能完全控制细菌的生长.

Dihydroxy nitro diphenyl ethers were prepared by acylation, nitration and hydrolysis from dihydroxy diphenyl ethers, then brominated by Br2 to give seven new brominated dihydroxy nitro diphenyl ethers. The structures of the new compounds have been confirmed by 1H NMR, IR, MS spectra and elemental analysis. These compounds showed good antimicrobial activities against the tested bacteria.