产妇无症状HBV携带者乳汁中HBV-DNA检测的意义

EFFECT OF THE DETECTION OF HBV DNA IN BREAST MILK OF SYMPTOMLESS PARTURIENTS WITH HBV

[目的]探讨无症状HBV携带产妇乳汁及血清中HBV-DNA含量的关系。[方法]应用荧光定量聚合酶链反应PCR法(FQ-PCR)检测166名无症状HBV携带产妇乳汁及血清中HBV-DNA含量,并分析其相关性。[结果]①166例无症状HBV携带产妇血清中HBsAg、HBeAg、HBV-DNA3指标阳性率分别为100%、59.0%、89.2%,均明显高于乳汁标本阳性率(P均﹤O.05)。②乳汁HBV-DNA含量与血清HBV-DNA含量呈正相关(r=0.56,P﹤0.01)。[结论]无症状HBV携带产妇乳汁和血清HBV-DNA具有正相关性,高病毒血症患者的乳汁具有较高传染性。

[Objective]To explore the relationship of the concentration of HBV-DNA in serum and breast milk of symptomless parturients with HBV.[Methods]By fluorescent quantitation polymerase chain reaction method（FQ-PCR）,HBV-DNA concentration in serum and the breast milk,and their relationship was analyzed.[Results]①The positive rates of HBsAg,HBeAg,HBV-DNA in blood of 166 symptomless parturients with HBV were 100%,59.0% and 89.2%,respectively,which were significantly higher than those in breast milk（P﹤0.05 for all the rate）. ② HBV-DNA concentration in breast milk showed significantly positive correlation with that in serum（r = 0.56,P﹤0.01）.[Conclusion]HBV-DNA concentration in serum and breast milk of symptomless parturients with HBV,those women with high HBV-DNA concentration had high infectivity.