新生儿耐甲氧西林凝固酶阴性葡萄球菌感染状况及耐药性监测

URVEILLANCE ON THE DRUG RESISTANCE AND INFECTION STATUS OF METICILLIN COAGULASE NEGATIVE STAPHYLOCOCCUS AMONG NEWBORN

[目的]探讨耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)在新生儿中的感染状况及其耐药性特点。[方法]应用API微生物分析鉴定系统对送检的临床标本进行鉴定,采用K-B法对鉴定出的菌株进行药敏试验,测定其对青霉素等17种常用抗生素的耐药性。[结果]从送检标本中共分离出MRCNS75例,其中血标本42例,占56.0%,气管分泌物23例,占30.7%,脓液及其他标本共10例,占13.3%;表皮葡萄球菌39株(52.0%)、溶血葡萄球菌17株(22.7%)、人葡萄球菌9株(12.0%)、其他10株(13.3%);药敏结果显示MRCNS多重耐药,对万古霉素全部敏感。[结论]凝固酶阴性葡萄球菌(CNS)为新生儿感染的重要致病菌,呈多重耐药性,应根据新生儿的病理生理特点及药敏结果合理使用抗生素。

[Objective]To discuss the distribution and features of drug resistance of methicillin resistant-coagulase negative staphylococcus（MRCNS）infections in neonates.[Methods]Isolates were cultured and identified by the total automatic API system and the resistance of MRCNS to 17 antibiotics was detected by K-B method.[Results]The 75 MRCNS strains were isolated from samples,among them,42 samples were blood samples accounted for 56.0%;23 samples of secretion from the trachea accounted for 30.7%;there were 10 samples of liquor puris,made up of 13.3%;39 strains（52.0%）were staphylococcus epidermidis,17 strains（22.7%）were haemolyticus staphylococci,9 strains（12.0%）were anthropo-staphylococci,and 10 strains were other kinds of staphyloccus. The results of drug allergic test showed that MRCNS revealed multi-drug resistance,and were sensitive to vancomyci.[Conclusion]MRCNS,showed multi-drug resistance,were the major causative germs for neonate infective disease,which requires more proper use of antibiotics in consideration of neonate.