吉西他滨联合顺铂治疗鼻咽癌肺转移的临床分析

Clinical analysis of lung metastasis from nasopharyngeal carcinoma treated with gemcitabine combined with cisplatine

目的观察吉西他滨联合顺铂（GP）方案治疗鼻咽癌肺转移的近期疗效与毒副反应。方法选择鼻咽癌肺转移病人24例，采用GP方案静脉化疗，21d为1周期，连续化疗4-6个周期。结果全组有效率（CR＋PR）79．1％（19／24），其中CR3例（12．5％）。毒副反应主要为骨髓抑制，其中Ⅲ～Ⅳ度白细胞减少下降达16．6％（4／24），Ⅲ～Ⅳ度血小板下降达12．5％（3／24），Ⅲ度贫血2例（8．3％）。结论GP方案化疗对治疗鼻咽癌肺转移有较好疗效。

Objective To observe the short term efficacy and toxicity of gemcitabine combined with cisplatin （GP） in treatment for lung metastasis from nasopharyngeal carcinoma. Methods 24 patients with lung metastasis from nasopharyngeal carcinoma were enrolled in this study, and all patients were administered GP chemotherapy every 21 days, and continuosly received 4-6 cycles chemotherapies. Results The overall response rate was 79.1% （19/24）, including 3 complete responses （12.5%）. Toxicity was mainly bone marrow depression. Grade Ⅲ/Ⅳ leucocytopenia and thrombocytopenia was 16.6% （4/24） and 12.5% （3/24）, respectively, and 2 patients （8.3%） were found grade Ⅱ anaemia. Conclusions Gemcitabine plus cisplatin chemotherapy may offer a satisfactory overall response rate and safety in lung metastasis from nasopharyngeal carcinoma.