壳聚糖基可注射型温度敏感性水凝胶

Chitosan-Based Injectable and Thermosensitive Hydrogel

壳聚糖基可注射型温度敏感性水凝胶是一种pH值中性的,在室温或低于室温时可保持液态,温度达到体温时可凝胶化的材料,有望被广泛应用于药物释放和组织工程领域,作为多肽和蛋白质等生物活性药物的可注射型释放载体或组织修复材料。本文介绍了壳聚糖基可注射型温敏性水凝胶的种类、特性、机制和应用等方面的研究进展。

The chitosan（CS）-based injectable and thermosensitive hydrogels are injectable liquid at low temperature and transform to semisolid hydrogels at body temperature. The formation of hydrogels is mainly due to the physical interactions such as hydrogen bonding, electrostatic interactions and hydropbobic interaction. Therefore, the thermosensitive hydrogels don＇ t require organic solvents, copolymerization agents, or an externally applied trigger for gelation, especially suitable for biomaterial applications. The CS/polyol salt combinations were firstly developed to produce thermosensitive neutral hydrogels. Many modified CS polymers, such as the PEG-grafted CS, N- isopropylacrylamide-grafted CS, Pluronic -grafted CS, hydroxybutyl CS and quatemized CS, also have thermosensitive characteristics. In this paper, the structure and properties of the chitosan-based thermosensitive hydrogels are simply introduced, and their applications in the field of drug delivery and tissue engineering are reviewed in detail.