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血浆内皮素在脑血管痉挛过程中的变化 被引量：1

Change of Endothelin Level in the Process of Cerebral Vasospasm
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摘要 目的:探讨血浆内皮素(ET)在脑血管痉挛(CVS)过程中的变化及其意义。方法:实验动物分为对照组与模型组,采用枕大池二次注血法建立脑血管痉挛动物模型,血管造影观察基底动脉痉挛,通过放射免疫法测定血浆ET。结果:模型组中血浆ET含量明显升高,第5d达峰值;3、5d组与对照组比有统计学意义(P<0.05)。结论:血浆ET可能是引起蛛网膜下隙出血后CVS的一个重要因素,且其水平与CVS的严重程度呈正相关。 Objective： To investigate the change of endothelin（ET）in the process of cerebral vasospasm（CVS）, and to evaluate its significance. Methods： The subjects were divided into the control group and the CVS group. ＂Two- hem- orrhage＂ method was used to establish the rabbit model, the angiography was performed to observe the cerebral vasospasm of the basilar artery and the ET level was determined with radioimmunoassay. Results： In the CVS group, the ET level in the blood plasma was increased, and reached peak in the day 5 group. The difference was significant（ P 〈 0.05）in the day 3 and the day 5 groups compared with the control group. Conclusion： ET may be one main cause which makes CVS after SAIl , and there is a positive correlation between the ET level and the CVS.
作者 柏鲁宁 周振国 康瑞刚 畅涛 王更新
机构地区 陕西中医学院附属医院神经(脑)外一科
出处 《汕头大学医学院学报》 2008年第1期45-46,49,F0003,共4页 Journal of Shantou University Medical College
关键词 蛛网膜下隙出血 脑血管痉挛 内皮素 subarachnoid hemorrhage cerebral vasospasm endothelin
分类号 R651.15 [医药卫生—外科学]
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参考文献5

  • 1Shigeru N, Ismail L. Signaling Mechanisms in Cerebral Vasospasm[J].TCM, 2005, 15(1): 24-34.
  • 2Broderick JP, Brott TG, Duldner JE, et al. Initial and recurrent bleeding are the major causes of death following subarachnoid hemorrhage[J]. J Stroke, 1994, 25(6): 1 342- 1 347.
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二级参考文献17

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汕头大学医学院学报
2008年 第1期

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