射频消融治疗小肝癌的临床研究

Radiofrequency ablation in the treatment of small live cancer

目的总结射频消融(RFA)治疗首诊直径≤3cm小肝癌的疗效和经验。方法采用徒手单人操作技术,多针、多点RFA治疗小肝癌21例,力争瘤体完全凝固。结果21例22个结节共行71点RFA,每个结节行3.2点RFA治疗,无一例发生严重并发症,无与射频治疗相关死亡。肿瘤完全凝固率100%(21/21),AFP转阴率80.0%(4/5);1、3、5年转移复发率分别是4.76%、19.0%、38.1%,1、3、5年生存率则为100%、80.0%、64.7%。结论RFA治疗小肝癌可使肿瘤完全凝固,疗效显著,完全可以替代手术切除而成为小肝癌的首选治疗方法。

Objective To investigate the efficacy of radiofrequency ablation（RFA） in the treatment of firstdiagnosed live cancer（ ≤3cm）and its experience. Methods Totally 21 cases of live cancer （≤3cm） underwent multi-needle and multi-point RFA in our hospital from Sep. 1999 to Dec. 2006 to achieve complete coagulation using single bare-handed method. AFP and enhanced scanning of CT were studied. Results Twenty two tumors of 21 cases received 71 points RFA, 3.2-point RFA per tumor. No serious complications and death related with RFA occurred. The rate of tumor complete coagulation was 100% （21/21）, the rate of AFP turned from positive to negative was 80.0% （4/5）, the 1 - , 3 - ,5 - year recurrence rate was 4.76%, 19.0% , 38.1% , respectively, the 1 - , 3 - , 5 -year survival rate was 100% ,80.0% ,64.7% with Kaplan-Meier, respectively. Conclusion RFA in the treatment of small live cancer（≤3cm） can achieve completely coagulation and excellent efficacy. It is the first choice for the treatment of small live cancer.