活体肾移植供者术后的回顾分析

Renal Function and Quality of Life in Live Relative Kidney Donors: A Post-procedural Review

目的:对亲属活体肾移植供者术后的肾功能和生活质量进行调查。方法:回顾性分析2000年5月-2007年4月亲属活体间捐肾的供者93例,对供者在捐肾手术前、手术后7 d,术后>6个月的血肌酐、内生肌酐清除率(Ccr)、尿蛋白情况进行检测,并利用国际上通用的SF-36健康调查量表对供者术后的生活质量进行调查。结果:供肾切取术后7 d和术前相比,供体血肌酐上升30.16μmol/L,上升幅度为38.5%(P=0.0000<0.05),差异有统计学意义但无临床意义(数值在正常值范围内);术后7 d和术后>6个月相比(P=0.1095>0.05)差异无统计学意义。供肾切取术后7 d和术前相比,Ccr下降38.44 mL/m in,下降幅度为40.1%(P=0.017<0.05),差异有统计学意义但无临床意义(数值在正常值范围内);术后7 d和术后>6个月相比(P=0.1095>0.05),差异无统计学意义。供者术后的生活质量评分比普通人群略低(但P>0.05)。结论:亲属活体肾移植的供者在捐肾后肾功能未见减退,且生活质量较好,和普通人群无明显差异。

Objective： To evaluate the renal function and quality of life after in live relative kidney donors the operation. Methods ：93 cases of live donor nephrectomy filed between May 2000 and April 2007 were reviewed for data on Scr,CCr and urine protein before,7 days and 6 months or more after the procedures. The internationally valid SF-36 scale was used to assess the postoperative quality of life. Results：At 7 days after surgery, the donors experienced an increase of 30. 16 μmol/L （ 38.5% ） in Scr from baseline （ P 〈 0.05 ）, which was statistically significant but not clinically relevant （within normal range）. No difference in Scr was found between results at 7 days and 6 months after surgery（P 〉 0.05） Ccr obviously decreased by 38.44 mL/min （40.18% ） after operation at the early stage, but still in normal range; there was no significant difference between early stage and long-term results （P 〉 0.05）. SF-36 score of donors was slightly lowered than that of general population, but no statistically significant （P 〉 0.05）. Conclusion 1 The renal function and quality of life of relative live donor was not shown to recede after operation, with no significant difference as compared with general population.