乙型肝炎病毒前S1抗原及HBV-M和HBV-DNA的关系

Relationship Between PreSl Antigen and other HBV markers,HBV-DNA

目的:探讨血清乙型肝炎病毒前S1抗原(PreS1)与HBV其他标志物及其DNA的关系。方法:对620例血清标本进行PreS1、乙肝病毒标志物和HBV-DNA检测。结果:在HBsAg、HBeAg、抗HBc与HBsAg、抗HBe、抗HBc和HBsAg、抗HBc三种阳性模式组,PreS1阳性率为84.8%、41.9%、51%。差异有显著性(P均<0.005)。在PreS1 (+)病例组,PreS1与HBeAg及HBV-DNA阳性率分别为58.87%、48.39%和51.61%,结果符合率达82.19%和87.67%。结论:血清PreS1主要存在于HBsAg携带者,且与HBeAg和HBV-DNA关系密切,是反映HBV复制及传染性的又一可靠血清学指标。PreS1联合HBV标志物同步检测具有重要的临床意义。

Objoctive To explore the relationship between PreS1 antigen（ PreS1 ）and other hepatitis B vires （HBV）markers, HBV-DNA. Mothods Pre-Sl antigen, HBV markers（ HBV-M ）and HBV-DNA in 620 sernm samples were detected. Rorults A-mong the three positive patterns with HBsAg. HBeAg,Anti-HBc or HBsAg, Anti-HBe, Anti- HBc and HBsAg, Anti- HBc,The positive rates of Pre-S1 antigen are 84.8% ,41.9% and 51% respectively, the differences were significant（ all P 〈 0.005 ）. In patients with PreSl,the positive rates of PreS1, HbeAg（ ＋ ） and HBV DNA were 58.87% ,48.39% and 51.61% . the coincident rate reach 82. 19% and 87.67%. Conclusion The results suggested that PreS1 mainly exists in patients with HBsAg （ ＋ ）, and has close relation with the condition of HBeAg and HBV-DNA. So it is another dependable index to reflect the HBV replication and infective activity, the synchronous detection of Pre-S1 with HBV markers has its important clinical meaning.