美托洛尔注射液控制非心脏手术围手术期时快速心室率的临床评价

Clinical therapeutic efficacy evaluation of perioperative intravenous metoprolol for control of ventricular rate in noncardiac surgery

目的研究美托洛尔静脉制剂用于控制非心脏手术围手术期时快速心室率的临床疗效和安全性。方法60例非心脏手术围手术期时快速心室率患者分别接受了静脉美托洛尔(A组,31例)和去乙酰毛花苷(B组,29例)治疗。结果两组患者心室率治疗后明显降低,A组31例,心室率平均下降(39±16)次/min,最大效应时间15min;B组29例,心室率平均下降(30±9)次/min,最大效应时间2h;两组患者用药前后血压无显著性变化,所有患者未因药物的副作用而终止治疗。结论美托洛尔静脉制剂能迅速有效、安全的控制非心脏手术围手术期时快速心室率反应。

Objective To observe the safety and efficacy of intravenous metoprolol for control of ventricular rate in noncardiac surgery. Methods Sixty patients were enrolled in either intravenous metoprolol group （31 cases） or intravenous Deslanoside （cedilanid） group （29 cases）. Results The heart rate of metoprolol group decreased 39±16beats/min. The ventricular rate control after 15 minutes of metoprolol administration was the most effective. The heart rate of Deslanoside group decreased 30±9 beats/ rain. The ventricular rate control after 2 hours of cedilanid administration was the most effective. No patients stopped study because of side effects. Conclusions Intravenous metoprolol is safe and effective in controlling ventricular rate of noncardiac surgery.