摘要
目的：通过对脑膜瘤术后复发组与术后未复发组的增殖细胞核抗原（Proliferating Cell Nuclear Antigen，PCNA）表达的检测，探讨其在脑膜瘤术后复发中表达的意义。方法：通过对内蒙古医学院附属医院神经外科在1998年1月～2000年12月手术后病理证实为脑膜瘤的210例患者的电话复访、信件回访及门诊复诊的回访，以复查过头颅CT或头颅MRI为标准，择出未见复发组42例，复发组19例，对其病理组织采用链霉菌抗生物素蛋白一过氧化物酶连接法（即S—P法）进行PCNA的测定，观察PCNA在不同组别中的表达差异。数据处理在SPSS 11、0软件包上分别进行平均数、标准差及相关性分析。结果：复发组PCNA阳性率高于未复发组。两组之间有明显的差异。结论：PCNA可作为预测是否复发的参考因素。
Objective：To detect the expression of proliferating cell nuclear antigen（PCNA） after surgery for meningoma and explore its significance in recurrence in meningoma. Methods： 210 cases undergoing surgery for meningoma from Jan. 1998 to Dec. 2000 in our hospital were followed up by telephone, letter or out-patient clinic. Based on CT or MRI image, 42 cases without recurrence and 19 cases with recurrent ones were selected, the level of PCNA were detected by S-P method and compared with SPSS 11.0 software. Results： The positive rate of PCNA in group with recurrent meningoma was higher than that in group without recurrence, the differ- ence was significant. Conclusion：PCNA may be referenced factor for predicting the recurrence in meningoma.
出处
《内蒙古医学杂志》
2007年第12期1414-1416,F0004,共4页
Inner Mongolia Medical Journal
关键词
脑膜瘤
术后复发
增殖细胞核抗原
Meningioma
Recurrence
Proliferating cell nuclear antigen（PCNA）
