摘要
目的:观察参芪益心颗粒对大鼠慢性心力衰竭血流动力学的影响。方法:以主动脉狭窄法造成大鼠慢性心力衰竭模型,术后1个月开始给药,给药后1个月结束试验,行左颈动脉、左心室插管,测定动脉血压(SAP)、左室压峰值(LVSP)、左室末期舒张压(LVEDP)、左室压最大上升速率(dp/dtmax),并观察药物对脏器指数、血浆血管紧张素Ⅱ(AⅡ)、心钠素(ANF)、血清醛固酮(ALD)、心肌Na+、K+、Ca++等各项相关指标的影响。结果:参芪益心颗粒可逆转由于主动脉狭窄所造成的后负荷增加导致的LVDEP,LVP,SAP,dp/dtmax增加,心脏指数、左室指数增加等心脏功能的异常改变,并改善心肌K+、Na+离子代谢,调整血浆AⅡ水平,与模型组比较均有显著性差异(P<0.05或P<0.01)。结论:参芪益心颗粒对慢性心衰所致心脏血流动力学、脏器指数等改变有明确的保护作用。
Objective： To study the effects of Shenqiyixin Granule on hemodynamics parameters of pressure overload heart failure rat model. Methods：A model of heart failure induced by coaretation of abdominal aorta was treated in the study. The drugs were taken by oral for 4 weeks from 4 weeks to 8 weeks after operation. Results： To compere with model,Shenqiyixin Granule can decreased LVEDP, LVSP, dp/dtmax, SAP, cardiac index, high-level of plasma AII and increased lower-level K^＋ in cardiac tissue. Conclusions：Shenqiyixin Granule may significantly improve hemodynemics and left ventricular function of heart failure rat.
出处
《中国实验方剂学杂志》
CAS
2007年第11期27-29,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家863课题(2002AAA2AZ346B)
