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体液细胞免疫在进行性肌营养不良症发病过程中的作用 被引量:3

Effects of humoral and cellular immunity in pathologic progress in PMD by immunohistochemistry
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摘要 探讨体液免疫和细胞免疫在进行性肌营养不良症(PMD)发病过程中的作用。方法应用免疫组化SP法及免疫荧光一步法。结果PMD肌组织中免疫球蛋白IgM、IgG和补体C3的阳性表达率分别为50.0%、31.1%和11.1%,IgM与对照组相比,差异有显著性意义(P<0.05),主要定位于肌膜和间质小血管壁上,与肌纤维萎缩性病变有关;PMD肌组织中有巨噬细胞和T淋巴细胞浸润,阳性反应率分别为100.0%和55.5%,巨噬细胞聚集在坏死灶中,T细胞分布于退变肌纤维和血管周围,以CD8+T细胞为主,多数表达HLA-DR。结论提示免疫因素可能参与PMD的病变过程。 Objective To study the effects of humoral and cellular immunity in pathologic progress in progressive muscular dystrophies (PMD). Methods Humoral and cellular immunity were studied in pathologic progress from 18 cases of PMD by immunohistochemistry (SP) and direct immunofluscence, and 11 cases of non muscular desease, nine cases of normal muscle were as controls. Result The positive rates of IgM, IgG and C3 were detected as 50.0%, 31.1%, and 11.1% respectively in PMD. Statistically significant IgM reaction was deposited as compared with controls ( P <0.05). The immune complex of positive reaction mostly located on the sarcolema and blood vessel walls, and were related to atrophy of myofibers. The positive rates of macrophage cells and T lymphocytes with infiltrated on muscle tissue were detected as 100.0% and 55.5% respectively. The macrophages mainly distributed to the necrosis lesions, while T cells mostly CD8 + surrounded degenerating myofibers and blood vessels and expressed HLA DR. Conclusion The results suggested that immunitive factor might be involved in pathologic progress in PMD.
出处 《中华神经科杂志》 CAS CSCD 1997年第5期262-264,共3页 Chinese Journal of Neurology
基金 福建省卫生厅科研基金
关键词 进行性 肌营养不良症 体液免疫 细胞免疫 Progressive muscular dystrophy Humoral immunity Cellullar immunity Immunohistochemistry
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参考文献2

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  • 2陈碧芬,骨骼肌疾病病理学,1993年,139页

同被引文献20

  • 1张成,陈维,肖露露,谭恩勋,罗绍凯,郑冬,叶欣,李中,卢锡林,刘颖.异基因脐带血干细胞移植治疗假肥大型肌营养不良症一例[J].中华医学杂志,2005,85(8):522-525. 被引量:7
  • 2张成,冯慧宇,黄绍良,方建培,肖露露,姚晓黎,陈纯,叶欣,曾缨,卢锡林,文剑明,张为西,李中,冯善伟,徐宏贵,黄科,周敦华,陈维,谢有梅,席静,张萌,黎阳,刘颖.脐血干细胞移植治疗假肥大型肌营养不良症[J].中华医学遗传学杂志,2005,22(4):399-405. 被引量:19
  • 3白芹,陈日新,白旭.肌营养不良症肌电图诊断的研究[J].江西医药,2007,42(4):343-345. 被引量:3
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